Immune

Front 1

primary lymphatic tissue

Back 1

site where lymphocytes arise and mature

Front 2

secondary lymphoid tissue

Back 2

site wher Abs are produced and effector Tcells func

Front 3

thymocytes

Back 3

immature t cells, within thymus they proliferate and differentiate and then migrate to peripheral lymphoid tissues.

Front 4

b cells mature?

Back 4

b cell precursons mature to immunocompetant b cells in bone marrow an then migrate to peripheral B cell tissues

Front 5

positive selection

Back 5

cells that are compatible with the ind's own MHC moleculres survive

Front 6

negative selection

Back 6

thymocytes that react with self Ag are eliminated. >95% apoptosis

Front 7

hassall's bodies

Back 7

onion like. unique to medulla, thymic corpuscles that consist of concentric arrangement of rightly would epi cells

Front 8

blood thymic barrier

Back 8

prevents circulating macromolecules within capillaries of cortex from entering cortex.

Front 9

types of cell in cortex of lymph node

Back 9

follicles or nodues which are dense collection sof B lymphocytes and macrophages

Front 10

germinal centers exist where?

Back 10

in lymph nodes of secondary follicle

Front 11

paracortex of lymph node contains what

Back 11

T lymphocytes, macrophages, Ag presenting cells

Front 12

Medulla of lymph node

Back 12

plasma cell and immunoblasts form medullary cords. btw cords are sinuses lined with macrophages.

Front 13

high endothelial venules

Back 13

postcap venules in cortex because of their distinctive endothelium. lymphocytes bind to endothelium and cross lining and them migrate to node. in absence of Ag just pass through to efferent

Front 14

spleen functions

Back 14

initiate immune res against blood borne Ag in white pulp, monitor and remove old or damaged blood cells in red pulp. Also site of differentiation of monocytes into macrophages, reservoir for platelets

Front 15

CT of spleen

Back 15

dense CT

Front 16

red pulp of spleen 2 structures

Back 16

thin walled venous sinus and splenic cords.

Front 17

PALS

Back 17

mostly T cells and macrophages

Front 18

walls of sheathed capillaries are made up of

Back 18

macrophages

Front 19

splenic sinuses

Back 19

long venous channels with unusual endothelium and BM. discontinuous epi. blood cells pass and cross sinus walls through spaces.

Front 20

difference btw thymus and lymph node

Back 20

thymus no b cells.

Front 21

pericortex contains

Back 21

t cells in lymph nodes.

Front 22

dendritic cells

Back 22

Ag presenting cells in lymph node medulla.

Front 23

what is unique about s venous sinusoid

Back 23

brach of splenic vein that has discontinuous endothelium.

Front 24

differences btw spleen and lymph node

Back 24

germinal center of white pulp always a central artery associated with follicle in spleen.

Front 25

Histo what to look for in thymus

Back 25

lobules, hassall's corpuscle in medulla, cortex, no lymphatic nodules

Front 26

histo lymph nodes

Back 26

look for cortex, medulla, lymphatic nodules

Front 27

hist spleen

Back 27

look for no cortex, no medulla, scattered lymphatic follicle, central artery next to lymphatic nodule.

Front 28

splenic cords

Back 28

reticular collagen III, where open cir is.