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28 Cards in this Set

  • Front
  • Back
primary lymphatic tissue
site where lymphocytes arise and mature
secondary lymphoid tissue
site wher Abs are produced and effector Tcells func
immature t cells, within thymus they proliferate and differentiate and then migrate to peripheral lymphoid tissues.
b cells mature?
b cell precursons mature to immunocompetant b cells in bone marrow an then migrate to peripheral B cell tissues
positive selection
cells that are compatible with the ind's own MHC moleculres survive
negative selection
thymocytes that react with self Ag are eliminated. >95% apoptosis
hassall's bodies
onion like. unique to medulla, thymic corpuscles that consist of concentric arrangement of rightly would epi cells
blood thymic barrier
prevents circulating macromolecules within capillaries of cortex from entering cortex.
types of cell in cortex of lymph node
follicles or nodues which are dense collection sof B lymphocytes and macrophages
germinal centers exist where?
in lymph nodes of secondary follicle
paracortex of lymph node contains what
T lymphocytes, macrophages, Ag presenting cells
Medulla of lymph node
plasma cell and immunoblasts form medullary cords. btw cords are sinuses lined with macrophages.
high endothelial venules
postcap venules in cortex because of their distinctive endothelium. lymphocytes bind to endothelium and cross lining and them migrate to node. in absence of Ag just pass through to efferent
spleen functions
initiate immune res against blood borne Ag in white pulp, monitor and remove old or damaged blood cells in red pulp. Also site of differentiation of monocytes into macrophages, reservoir for platelets
CT of spleen
dense CT
red pulp of spleen 2 structures
thin walled venous sinus and splenic cords.
mostly T cells and macrophages
walls of sheathed capillaries are made up of
splenic sinuses
long venous channels with unusual endothelium and BM. discontinuous epi. blood cells pass and cross sinus walls through spaces.
difference btw thymus and lymph node
thymus no b cells.
pericortex contains
t cells in lymph nodes.
dendritic cells
Ag presenting cells in lymph node medulla.
what is unique about s venous sinusoid
brach of splenic vein that has discontinuous endothelium.
differences btw spleen and lymph node
germinal center of white pulp always a central artery associated with follicle in spleen.
Histo what to look for in thymus
lobules, hassall's corpuscle in medulla, cortex, no lymphatic nodules
histo lymph nodes
look for cortex, medulla, lymphatic nodules
hist spleen
look for no cortex, no medulla, scattered lymphatic follicle, central artery next to lymphatic nodule.
splenic cords
reticular collagen III, where open cir is.