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30 Cards in this Set

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Autoimmune diseases
A large grop of diseases characterized by the subversionor alteration of the function of the immun system where th immune response deircted against normal tissue of the body, resulting in pathologic conditions pg 747
Graft
The term used for a transplanted tissue or organ pg 751
Immune-mediated diseases
A large group of dieseases that result when the cells of the immune syste reat to a variety of situations such as transplanted organ tissue or drug alter cells pg 747
Immunosuppressant
A drug treatment used to suppress the immune system pg 748
Immunosuppressive therapy
A drug treatment used to suppress the immune system
Murine antibodies
Monoclonal immunoglobulins Monoclonal refers to aprotein from a single clone of cells all molecules of the protein are idential. Murine refers to the family Mridae to twheich mice belong. An antibody is a protective protein that counters the ations of antigens substances that cauase sensitivity or an allergic response thus murine antibodies are protectvie proteins obtained from mice. Moromanab CD3 is am urine antibody used to rverse graft rejetion pg 751
Muromonable-CD3
Prvents T-cells from recognizing foreign antigens and is used in transpant recipients suffering from acute rejection of the donated organ. It is used to prvent actue rejection and is considered to be a pent immunosuppressant
Active immunization
a process that causes a complete and long lasting immunity to infection to develop through exposure of the body to a realtively harmless from of the antigen. This imprints a memory on the body's immue system and stimulated the body's fesnss to synthesize antibodies to fend off any subswequent exposure to theantigen pg 757
Active immunizing agents
Same as toxiods or vaccines to stimulate hst production of antibodies pg 758
Antibody
Immunoglobuline molecules that have an antigen specific amino acid sequence and are synthesized by the humoral immune system in response to expposure to a specific antigen to attack and destroy molecules of the antigen pg 761
Antibody titer
Amount of an antibody needed to react with a given volume or amount of a specific antigen pg761
Antigen
A substance usually a protein and freign to a host that causes the formation fo an antibody and reacts specifically with that antibody Examples of antigens incude bacterial exotoxins and viruses An allergen 756
Antiserum
A serum that contains antibody or antibodies It is usually obtained from an animal that has been immunized against a specifi antigen, either by injection with the antigen or by infection with sepcific microorganisms that produce the antigen. pg 759
Antivenin
An antibody or antiseruma gians a venom produced by an animal used to treat humans or other animals that have been envenomed pg759
Biiological antimicrobial agent
substant of biologic origine used to prevent treat or cure infectious diseases. thes agents are ofter simply referred to as biologicals. However that term may also be used to refer to agents of bioterrorism depending on contex pg 757
Cell mediated immune system
The immune response that is mediated by T-Cells
Herd Immunity
Resistance to diseas in an entire community orpopulation because a large proprotion of members are immune
Immune response
A cascade of biochemical events that occures in response to entry into the body of an antigen Key processes of the immune respponse include pahgocytosis of foriegn microorganisms
Immunizeing biological
Toxoid or vaccine targeted against an infectious microorganism
Passive immunization
A process that fights infection by bypassing the immune system.. it inovles giving a person serum or cncentrated immune globulines obtained diretyly fromhumans or animals
Passive imunizing agents
Agents containing antibodies that can kill or inactivate pathogent.
Toxoid
A modified a inactivated by chemicals or heat bacerial exotoxin that is no longer toxic but can still bind and or stimulate the formationof antitoxin often used in the samemanner as a vaccine one type of active immunization
Vaccine
A suspension of live attenuated or killedmacroorganizms that can promote an artificially cultivated active immunity against a prticular microorganism. It is another type a ctive immunizing agent
Dose limmiteing side effects
Side effects that prvent the antineoplastic agent fro being given in height doses often limiting the effectiveness of the drug
Nadir
Lowest point in any fluctuation value overtime such as thewhite blood cell count after ithas been depressed by chemotherapy With antineoplastic drug therapy this term also refers to the time frame which these drugs kill the greatest number of bone marrow cells
Antibody
An immunogoglobuline that binds to antigens to form an antigen antibody complex This process serves to inactivate friegn atigens that enter the body and are capableof causing disease
Cytokines
The generic term for nonantibody proteings released by one cell population on contact with antigens. Cytokines act as intrcellular mediators of an immune response. Although not cytokines are antibodies all cytokines are proteins
Interferon
One type of cytokine that promotes resistance to viral infection in unifected cells and can also strengthen the bodys' immune respnsonse against cancer cells
Memory cells
Cells involved inthe humoral immune system that remember the exact characteeristics of a particular foreign invader or antigen
T-Cells
Leukocytes ofthe cell mediated immue system Unlike b-cells they are not involved in the production of antibodies but instead have varous cell subtypes.