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57 Cards in this Set
- Front
- Back
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ALL - inc
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most common leukemia of early childhood
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ALL - def
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immature lymphoblasts are produced with no further differentiation
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ALL - clin man
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acute onset
fatigue malaise bone pain sweats bleeding easy bruising |
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ALL - labs
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pancytopenia
elevated WBC elevated uric acid and LDH |
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ALL - blasts
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30-100% in bone marrow
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ALL - special
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philadelphia chromosome
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ALL - tx
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chemo
CNS prophylaxis bone marrow transplant |
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AML - inc
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most common in older adults
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AML - def
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uncontrolled proliferation of primitive hematopoetic cells
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AML - clin man
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acute onset
malaise bone pain sweats bleeding easy bruising petechiae pallor ecchymyosis |
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AML - unique finding
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auer rods
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AML - blasts
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30-100%
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AML - labs
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anemia
thrombocytopenia |
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AML/ALL - general
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rapid proliferation of immature cells that don't die crowding out normal blood cells
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AML - tx
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chemo
bone marrow transplant |
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hodgkins - def
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malignant disorder of the lymphatic system that mainly affects lymph nodes
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hodgkins - onset
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20-30 and <50
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hodgkins - spread
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continguous from lymph node to lymph node
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hodgkins - unique findin
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reed stern berg cells - large multinucleated cels
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hodgkins - lab finding
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anemia
ESR |
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hodgkins - stagin
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ann arbor
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hodgkins - nodes
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firm
freely mobile nontender |
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hodgkins - clin man
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pruritis
disulfiram rxn to ETOH |
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hodgkins - tx
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radiation therapy
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hodgkins - prognosis
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85% curable
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non hodgkins - def
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solid tumor of the immune system
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non hodgkins - lymphadenopathy
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cervical
axillary inguinal region |
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non hodgkins - clin man d/t
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mediastinal and retroperitoneal lymphadenopathy
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non hodgkins - clin man
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chest pain
cough abdominal/back pain |
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non hodgkins - tx
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surgical excision
radiation chemo |
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MM=multiple myeloma
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MM
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MM - def
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neoplastic proliferation of a single clone of a plasma cell
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MM - inc
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common > 65
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MM - clin man
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bone pain
weakness fatigue |
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MM - unique finding
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bence jones protein in urine
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MM - xray
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punched out lytic lesion
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MM - RBC morphology
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normocytic
normochromic anemia |
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ITP=idiopathic thrombocytopenia purpura
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ITP
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ITP - def
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AI bleeding disorder where its develop antibodies against their own platelets
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ITP - clin man
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no splenomegaly
superficial bleeding of skin, mucous membranes and GU tract |
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ITP - labs
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decr platelet count
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ITP - must r/o
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DIC with coagulation studies
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ITP - coag studies
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normal!!!!
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ITP - tx (2)
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steroids
possible splenectomy |
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ITP - drugs that worsen
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bactrim
cillins fursomide phenytoin cimetidine |
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TTP=thrombotic thrombocytopenia purpura
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TTP
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TTP - def
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severe thrombocytopenia
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TTP - clin man
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fever
neuro abnormalities GI signs and sx ARF severe HTN |
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TTP - coag studies
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normal
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TTP - unique features
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schistocytes
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TTP - labs
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incr ret count
incr LDH |
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TTP - tx
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large volume plasmapheresis
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PV=polycythemia vera
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PV
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PV - def
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elevated red blood cell mass which increases risk of developing AML
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PV - clin man
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ruddy complexion
splenomegaly LUQ pain thrombosis |
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PV - labs
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incr H&H
incr RBC mass |
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PV - tx
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periodic phlebotomy
hydroxyurea to control red cell mass |
