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5 Cards in this Set
- Front
- Back
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List the mechanism of fever
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Exogenous pyrogens (e.g. bacterial products)
-> Stimulates release of endogenous pyrogens (e.g. IL-1, TNF α) from leukocytes ->Increased cyclooxygenase (COX) activity = prostaglandin production -> Hypothalamus: Prostaglandins (esp. PGE2) stim. H to raise temp set point -> Heat conservation and production |
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What are pyrogens?
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Anything that causes a fever
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Apart from endo. pyrogens, what also stimulates cyclooxygenase (COX) activity (i.e. production of prostaglandins)?
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NSAIDS (Non-steroidal anti-inflammatory drugs)
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What are somem endogenous pyrogens?
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Interleukin-1, Tumour Necrosis Factor α.
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List mechanisms of heat conservation and production
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Skin vasoconstriction,
piloerection (goose bumps), shivering, adenergetic effects including raised metabolism Heat-seeking behaviour (warm clothes and drink) |
