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11 Cards in this Set
- Front
- Back
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Name the Effectors for Intracellular Immune response
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(in order of appearance with peak in parenth)
INF (2 days) NK (4 days) Neutralizing ABs & CTLs(7-10 days) |
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Mediators in NK cells
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Perforins (holes like C9) Granzymes (DNA damage)
IFN g (activate MPs) |
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Activation of Tc's
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IL-2 (from Th1's)
requires MHC I & II MHC I: APC + antigen stimulates expression of IL-2 R on CD8 T (B7 binds CD28) MHC II: Th1 bound to APC + Ag at same time as CD8 is bound, releases IL-2 |
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Mediators from Tc's
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granzyme, perforin, cytokines (TNF & IFN)
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ADCC
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NKs working with Neutralizing ABs
activation of Fc R on NK important for worms & tumors IgG & IgE (no Ag R on NK) |
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MOA for Rimantidine
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Uses M2, interferes with uncoating of Influenza A only
Prophylactic within 24 hours of exposure used w/L Dopa in Parkinson's |
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MOA for Omseltavir
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(& Zanamavir)
Neuraminidase inhibitor Prevents viral release Influenza A & B |
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MOA for Acyclovir
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recognizes thymadine kinase
inhibits DNA synthesis HSV & EBV (not CMV) |
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Gangcyclovir
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for CMV, inhibit viral DNA synthesis
not as specific as Acyclovir BM tox, Nephrotox, GI contraindicated w/AZT (b/c BM) |
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Ribavirin
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inhibits viral mRNA & 5' cap
BM tox, Nephrotox, GI Hanta, RSV bronchiolitis & pneumonia Use w/interferon for Hep C |
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Idoxuridine
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BM toxicity, carcinogenic, teratogenic
MOA is DNA damage Used topically for HSV kerititis |
