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16 Cards in this Set
- Front
- Back
3 products of arachadonic acid
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Leukotrienes (lipooxegenase)
Thromboxanes (COX 1) Prostaglandins (COX 2) |
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Action of Leukotrienes
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chemotaxis- eosinophils
vascular permeability |
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Action of Thromboxanes
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platelet aggregation
(clotting) smooth muscle constriction (via lowered cAMP) |
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Action of prostaglandins
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inhibit platelet aggregation
(via increased cAMP) smooth muscle dilation (except PGD2) Keep ductus arteriosis open |
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first generation H1 blockers
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dyphenhydramine
chlorpheniramine promethazine allergies, anti-nausea, sedation |
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second generation H1 blockers
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Citirizine
Fexofenadine Loritidine allergies w/o sedation no anti nausea |
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H2 blockers
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Ranitidine (ramantidine is flu treatment)
Cimetidine |
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action of NSAIDS
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antipyretic, anti-inflammatory, pain
|
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NSAIDs use & special SE
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Asprin-
(inhibit plt aggregation, Reyes) Ibuprofen- GI distress Indomethicin- only inflamm close ductus arteriosis (PGs keep open) |
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Non- NSAID
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Acetominophin
no anti-inflamm liver toxic b/c quinone metabolites (glutithione) Tx w/n-acetylcysteine |
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action of histamine binding H1 receptor
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acts on vessels
(initial increase IP3 & DAG) increase EDRF (NO) & cGMP vasodilate, vascular perm (kinin), increase HR (reflex tachy) |
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action of histamine binding H2 receptor
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acts on gut mucosa
increase cAMP & GI acid |
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side effects of LT receptor inhibitors
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interfere with metabolism of Warfarin & theophyline
|
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TNF alph inhibitors use & SE
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treat RA
increases infection & lupus exacerbate demyelinating dz heart failure |
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DSMARDs
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disease modifying anti-rheumatic drugs
hydroxychloroquine (malaria) Penicillamine (chelating agent) cyclosporin, glucocorticoids, leflunomide, gold salts (immunosuppres & cytos) methotrexate (antineoplastic) |
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action of Anakinra
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IL-1 Inhibitor
tx RA |