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16 Cards in this Set

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  • Back
3 products of arachadonic acid
Leukotrienes (lipooxegenase)
Thromboxanes (COX 1)
Prostaglandins (COX 2)
Action of Leukotrienes
chemotaxis- eosinophils
vascular permeability
Action of Thromboxanes
platelet aggregation
(clotting)
smooth muscle constriction
(via lowered cAMP)
Action of prostaglandins
inhibit platelet aggregation
(via increased cAMP)
smooth muscle dilation (except PGD2)
Keep ductus arteriosis open
first generation H1 blockers
dyphenhydramine
chlorpheniramine
promethazine

allergies, anti-nausea, sedation
second generation H1 blockers
Citirizine
Fexofenadine
Loritidine

allergies w/o sedation
no anti nausea
H2 blockers
Ranitidine (ramantidine is flu treatment)
Cimetidine
action of NSAIDS
antipyretic, anti-inflammatory, pain
NSAIDs use & special SE
Asprin-
(inhibit plt aggregation, Reyes)
Ibuprofen- GI distress
Indomethicin- only inflamm
close ductus arteriosis (PGs keep open)
Non- NSAID
Acetominophin
no anti-inflamm
liver toxic b/c quinone metabolites (glutithione)
Tx w/n-acetylcysteine
action of histamine binding H1 receptor
acts on vessels
(initial increase IP3 & DAG)
increase EDRF (NO) & cGMP
vasodilate, vascular perm (kinin), increase HR (reflex tachy)
action of histamine binding H2 receptor
acts on gut mucosa
increase cAMP & GI acid
side effects of LT receptor inhibitors
interfere with metabolism of Warfarin & theophyline
TNF alph inhibitors use & SE
treat RA
increases infection & lupus
exacerbate demyelinating dz
heart failure
DSMARDs
disease modifying anti-rheumatic drugs
hydroxychloroquine (malaria)
Penicillamine (chelating agent)
cyclosporin, glucocorticoids, leflunomide, gold salts (immunosuppres & cytos)
methotrexate (antineoplastic)
action of Anakinra
IL-1 Inhibitor
tx RA