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62 Cards in this Set
- Front
- Back
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What are most type of Non-Hodgkins Lymphoma?
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B cell
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Most common cause of lymphadenopathy
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infection
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Most common malignant cause of lymphadenopathy
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met. carcinoma
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Tingible body macrophages
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When macrophages have ingested cell debris
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Area of the lymph node that contains T cells
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interfollicular area
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What disorder would you see tingible body macrophages
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Follicular hyperplasia
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Large, irregular follicles with a mix of cells in the germinal centers
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Follicular Hyperplasia
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B cell response to some immune stimulus
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follicular hyperplasia
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Partial effacement
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Interfollicular hyperplasia
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Expanded area between follicles
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Interfollicular hyperplasia
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T cell response to some immune stimulus
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Interfollicular hyperplasia
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Malignant follicular lymphoma architecture, follicle size and shape
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effaced arch, uniform
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What would a germinal center look like in malignant follicular lymphoma?
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NO mantle zone, NO tingible body macrophages and more monotonous lymphocytes
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Difference between Hodgkin and Non Hodgkin
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Hodgkin is fairly predictable and has a good prognosis
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Malignant proliferation of lymphoid cells (blasts or mature cells) in lymph nodes
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Non Hodgkin Lymphoma
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Type of Hodgkin that skips around
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Non Hodgkin
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What are most of the subtypes of Non-Hodgkin?
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B cell
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What type is Small lymphocytic lymphoma?
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Low-grade NH
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What type is marginal zone?
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low grade NH
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What type is mantle cell?
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low grade NH
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What type is follicular lymphoma?
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low grade NH
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What type is mycosis fungoides/Sezary syndrome?
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low grade NH
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What type is diffuse large B cell lymphoma?
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High grade NH
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What type is lymphoblastic lymphoma?
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High grade NH
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What type is Burkitt lymphoma?
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High grade NH
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What type is adult T cell leukemia/lymphoma?
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High grade NH
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Which grade of NH RARELY affects the young?
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low grade
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Which grade of NH is extranodal involvement common?
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high grade
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SLL = ?
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CLL
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B cell lesion, but still CD5+!
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SLL/CLL
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Proliferation centers are visible at low power
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SLL/CLL
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MALT lymphoma
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Marginal zone lymphoma
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Often goes away when you tx for helicobacter pylori
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MALT (marginal zone) lymphoma
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Where does MALT most commonly occur?
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stomach
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Marginal zone pattern
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MALT
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Small, angulated lymphocytes
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Mantle cell lymphoma
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What translocation does mantle cell lymphoma have?
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t(11;14), bcl-1 and IgH
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One of the most common types of NH lymphoma
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Follicular
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What translocation does follicular lymphoma cells have?
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t(14;18) which involves bcl-2 and IgH
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Paratrebecular aggregate
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Follicular lymphoma
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Butt Cells
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Follicular lymphoma (Grade 1)
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Small, cleaved, or mixed large cell
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Follicular lymphoma
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Mycosis fungoides/Sezary, T or B cell?
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T cell
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Skin lesions that start as patches and move to nodules
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Mycosis Fungoides
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Pautrier Microabscesses
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Mycosis fungoides (collections of lymphoma cells in the epidermis)
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Cerebriform lymphocytes
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Mycosis fungoides
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Prognosis of Diffuse Large B cell lymphoma
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Poor
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Grows rapidly and presents early with extranodal (spleen) involvement
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Diffuse large B cell lymphoma
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B lineage lymphoblastic lymphoma =
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Precurosr B cell leukemia/lymphoma
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T lineage lymphoblastic lymphoma =
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T cell ALL
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Lymphoblastic Lymphoma =
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ALL
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Teen male with mediastinal mass
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T lymphoblastic lymphoma or T cell ALL
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Translocation of Burkitt
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t(8,14)
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What 2 disorders/diseases do you see tingible body macrophages?
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Burkitt lymphoma and follicular hyperplasia
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Japan/Caribbean Basin
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Adult T cell Leukemia/Lymphoma
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Flowery nuclei
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Adult T cell leukemia/lymphoma
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What infection is Adult T cell leukemia/lymphoma associated with?
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HTLV-1
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Skin lesions and hypercalcemia
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Adult T cell leukemia/lymphoma
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What type of patients does Hodgkin occur in?
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younger, good prog
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Reed Sternberg cell
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Hodgkin disease
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What is the most important prognostic factor of Hodgkin?
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Stage
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Patients may develop second malignancies due to the long survival rate in this disease
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Hodgkin
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