Iho: Lymph Histology

Front 1

Name examples of non-encapsulated nodular lymphatic tissue

Back 1

Tonsils, Peyer's patches, appendix

Front 2

Consists of groups of lymphatic nodules situated mostly in the wall of the ileum of the SI

Back 2

Peyer's patches

Front 3

Functions of non-encapsulated lymphatic tissues?

Back 3

trap and destroy antigen also lymphocyte production in response to antigen : B-cell proliferation

Front 4

Only lymphatic organ located in course of lymphatic vessels

Back 4

Lymph Node

Front 5

Only lymphatic organ that has lymphatic sinuses

Back 5

Lymph Node

Front 6

Only lymphatic organ that filters lymph

Back 6

Lymph Node

Front 7

What filters lymph in the lymph node?

Back 7

Macrophages

Front 8

Which are more efficient APC?

Back 8

DCs are more efficient than macrophages

Front 9

What type of cells line sinusoids?

Back 9

endothelial cells

Front 10

Indentation of LN?

Back 10

Hilum

Front 11

Bind antigen-antibody complexes but do not endocytose and process antigen

Back 11

Follicular dendritic cells (FDCs)

Front 12

FDCs are NOT

Back 12

APCs

Front 13

You may see afferent lymphatic vessels on a LN everywhere except...

Back 13

Hilum region

Front 14

Lymphatic Nodules have tails that extend into the medulla as?

Back 14

Medullary Cords

Front 15

If under insult, a lymphatic nodule will have what?

Back 15

Germinal center

Front 16

Contains the medullary cords

Back 16

Medulla

Front 17

What lie between the medullary cords?

Back 17

Medullary sinus

Front 18

The medulla of a LN contain a large amount of what?

Back 18

small B lymphocytes

Front 19

Between capsule & outer limits of germinal centers

Back 19

Superficial cortex

Front 20

The superficial cortex primarily has what cells?

Back 20

B lymphocytes

Front 21

Area containing the germinal centers
in a LN

Back 21

Mid-cortex

Front 22

Primary cells in mid-cortex of LN?

Back 22

B-cells

Front 23

AKA paracortex

Back 23

Deep cortex

Front 24

Between germinal centers & medullary cords

Back 24

Deep cortex/Paracortex

Front 25

Primary cells in paracortex

Back 25

T-lymphocytes

Front 26

How do lymphocytes enter the lymphatic sinuses and leave the LN?

Back 26

Via efferent lymphatics at hilus (become part of recirculating lymphocytes)

Front 27

Lymph Flow through LN

Back 27

Afferent vessels, subsacsular sinus, trabecular sinus, paracortical sinus, meduallry sinus, efferent lymphatic vessel

Front 28

Where do arteries come in veins leave the LN?

Back 28

Hilus

Front 29

What are the deep (paracortex) post-capillary venules lined with?

Back 29

Simple cuboidal (HEVs) (NOT simple squamous!)

Front 30

What are most BV lined with?

Back 30

Simple Squamous Epithelium (Except deep HEVs

Front 31

Where can lymphocytes pass through BV?

Back 31

in the HEVs; simple cuboidal epithelium

Front 32

Site of passage of lymphocytes (T- & B-lymphocytes) from blood vessels into lymphatic tissue

Back 32

HEVs

Front 33

What would a thymectomy cause?

Back 33

HEV endothelium reverts to simple squamous

Front 34

More than 95% of lymphocytes in the efferent lymphatic vessels are derived from where?

Back 34

Lymphocytes which migrated through the HEVs

Front 35

Name 3 functions of the LN

Back 35

lymph filter (macrophages), lymphocyte production, antibody production (plasma cells)

Front 36

What does the thymus lack?

Back 36

afferent lymphatic vessels

Front 37

2 primary lymphatic organs in the body

Back 37

thymus and Bmarrow

Front 38

Describe the maturation of the thymus

Back 38

It increases in size until puberty and then gradually < in size and is replaced by fat tissue

Front 39

From what pouch is the thymus derived?

Back 39

3rd pouch

Front 40

From what matter is the thymus derived?

Back 40

Endoderm

Front 41

Produce a # of thymic hormones

Back 41

Reticular cells

Front 42

Help form blood-thymus barrier

Back 42

Reticular cells of thymus

Front 43

Loose cellular network which supports the developing T-lymphocytes

Back 43

Reticular cells of the thymus

Front 44

Contain largest lymphocytes in the cortex of the thymus

Back 44

Outer region

Front 45

Contain the smallest lymphocytes of the cortex of the thymus and cell division is not evident

Back 45

Inner region of the thymus

Front 46

What is the characteristic feature of the medulla of the thymus?

Back 46

Hassall's corpuscles (NEVER in the cortex of the thymus!)

Front 47

What is the primary cell of the medulla of the thymus?

Back 47

Epithelial reticular cells

Front 48

What are the major branches of vascular supply to the thymus?

Back 48

Internal thoracic and inferior thyroid arteries

Front 49

Where would you find capillary loops in the thymus?

Back 49

Cortex of thymus

Front 50

Serves to prevent antigens present in the blood stream from entering the cortex

Back 50

Blood-thymus barrier

Front 51

Results in the patient lacking T-lymphocytes, and therefore, cellular immunity

Back 51

Congenital absence of the thymus

Front 52

Most common tumor found in the anterior mediastinum

Back 52

Thymomas

Front 53

Neoplasms of the thymus reticular cells

Back 53

Thymomas

Front 54

Largest lymphatic organ

Back 54

Spleen

Front 55

What does the spleen lack

Back 55

Afferent lymphatic vessels and lymph sinuses

Front 56

Important area of the spleen where many structures enter and exit

Back 56

Hilus

Front 57

Does the spleen have a cortex or medulla?

Back 57

NO! It has red or white pulp instead

Front 58

What does the spleen have instead of a cortex or medulla?

Back 58

Red or White pulp

Front 59

Occupies space between trabeculae in the spleen

Back 59

splenic pulp (supported by reticular stroma)

Front 60

What type of splenic pulp has PALS?

Back 60

White

Front 61

Surround white pulp artery (central artery)

Back 61

PALS of white pulp

Front 62

What type of cells do PALs contain?

Back 62

T-cells

Front 63

What do the splenic nodules of the white pulp contain?

Back 63

B-cells

Front 64

2 components of white pulp?

Back 64

PALS and Splenic/Lymphatic nodules

Front 65

2 components of red pulp?

Back 65

Splenic sinuses (sinusoids) and Splenic cords (Billroth cords)

Front 66

Vascular passageways lined by specialized endothelial cells of red pulp?

Back 66

Splenic sinuses (sinusoids)

Front 67

Located between the sinuses of red pulp

Back 67

Splenic cords (Billroth cords)

Front 68

The transitional zone between the red & white pulp

Back 68

Marginal zone

Front 69

Small blood vessels dump their blood into this area or the red pulp

Back 69

Marginal zone

Front 70

Terminal capillaries open into sinusoids

Back 70

Closed Circulation

Front 71

Terminal capillaries open into red pulp

Back 71

Open circulation

Front 72

Body's main source of circulating antibody

Back 72

spleen

Front 73

Conentration and storage of BC and platelets

Back 73

Spleen

Front 74

What type of splenic circulation is thought to occur in humans?

Back 74

Open

Front 75

Represents local immune responses to antigens

Back 75

Nodular lymphatic tissue

Front 76

What type of nodules do not appear until after birth?

Back 76

Secondary lymphatic nodules (decline with age)

Front 77

What disappear in the absence of antigen?

Back 77

Secondary lympatic nodules

Front 78

Lymphatic nodule are present in the ____ and ____ but NOT in the ____

Back 78

LN and spleen but NOT in the thymus

Front 79

What type of cells may be found at the periphery of the germinal center?

Back 79

Plasma cells