Iho : Antigen Presentation And Processing

Front 1

Unless what occurs, adaptive immunity does not develope

Back 1

Activation of T cells

Front 2

What is constitutively expressed by B cells?

Back 2

MHC II

Front 3

What is required for the activation of naieve T cells but NOT for Effector or Memory T cells?

Back 3

B7

Front 4

At the resting state, which APCs can activate Effector and Memory cells?

Back 4

Dendritic, B lymphocyte

Front 5

At the resting state, which APC can activate naive T cells?

Back 5

Dendritic cell (It has B7 at resting state)

Front 6

What presents toxins?

Back 6

B cells

Front 7

This pathway is used for the presentation of endogenous antigens

Back 7

Cytostolic pathway

Front 8

What pathway will DRiPs undergo?

Back 8

Cytosolic

Front 9

Rapidly degraded proteins that are synthesized incorrectly that may perisst in the cytosol as peptides

Back 9

Defective Ribosomal Products (DRiPs)

Front 10

Which pathway uses Ubiquitin

Back 10

Cytosolic (Class 1)

Front 11

What pathway uses TAP

Back 11

Cytosolic (1)

Front 12

In which pathway is the ER involved?

Back 12

Cytosolic (1)

Front 13

What special items are needed when a normal protein is forced through the proteasome?

Back 13

Ubiquitin and 26S proteasom; 19S allow ubiquitin to dock

Front 14

What proteasome degrades misfolded proteins?

Back 14

20S

Front 15

What 2 rings are associated with enzymatic cleavage of proteins in the cytosolic pathway?

Back 15

Inner 2 (Outer 2 unwind the protein)

Front 16

Where are MHC 1 molecules synthesized?

Back 16

ER

Front 17

Where are the peptides from the cytosol of cytosolic degradation transferred to?

Back 17

ER where Class 1 molecules are made

Front 18

What can make peptides favored by TAP and MHC 1 moleculs?

Back 18

Immunoproteasome shows bias towards > cleavage after hydrophobic aa and reduced cleavage after acidic aa

Front 19

Where does Immunoproteasome show increased cleavage?

Back 19

hydrophobic aa

Front 20

What is the function of TAP?

Back 20

PIck up peptide, protect it, funnel it through ER and place it on MHC 1

Front 21

On what side of the ER do peptides emerge after association with TAP?

Back 21

lumen

Front 22

What kind of affinity does TAP display?

Back 22

aa of 8-16, peptides with a hydophobic or basic carbozyl-terminal (Also the same for MHC 1!)

Front 23

Final trimming of the peptide after TAP is done by what?

Back 23

ERAP1 (ERAP 2 degrades peptides too small for MHC 1)

Front 24

What does Calnexin do?

Back 24

Assists in proper folding of MHC 1

Front 25

When is Clanexin released?

Back 25

When MHC 1 alpha becomes associated with Beta 2 microglobulin chain

Front 26

What does ERp57 do?

Back 26

Keeps the jaws of MHC 1 open

Front 27

What does Calreticulin do?

Back 27

Chaperone protein for the assembly of MHC 1

Front 28

What is the signal for MHC 1 to move to the outer surface of the cell membrane?

Back 28

Insertion of the antigenic peptide into class 1 groove

Front 29

What happens to peptides not protected by TAP?

Back 29

They are degraded

Front 30

Are DRiPs ubiquitin ticked?

Back 30

NO (They are abnormal)

Front 31

What will happen in a TAP deficiency?

Back 31

Overactive NK cells, thus necrotizing granulomatous lesions of skin o face and extremeties

Front 32

How do B cells internalize antigens?

Back 32

Receptor-mediated endocytosis

Front 33

What is a chaperone protein of the endocytic pathway?

Back 33

Invariatnt chain

Front 34

Where is MHC 2 made?

Back 34

ER

Front 35

What is left when the invariant chain is digested from the Golgi through the endocytic pathway?

Back 35

CLIP

Front 36

What presents nonpeptide antigens?

Back 36

CD1

Front 37

What prevents the binding of an endogenous antigen in the Exogenous pathway?

Back 37

binding of invariant chain to MHC II