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20 Cards in this Set
- Front
- Back
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Anti-centromere Ab
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related to localized scleroderma
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Anti-dsDNA Ab
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related to nephritis in SLE
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Anti-Jo1 Ab
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related to myositis
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Anti-La Ab
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associated with absence of renal disease in SLE; presence in mother associated with congenital complete heart block (permanent) & neonatal lupus dermatitis in fetus (temporary)
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Anti-mitochondrial Ab
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releated to 1° biliary cirrhosis
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Antineutrophil cytoplasmic Ab
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characteristic of Wegener’s granulomatosis
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c-ANCA
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cytoplasmic pattern of distribution; closely associated with Wegener’s granulomatosis
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p-ANCA
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perinuclear pattern of distribution; more commonly found in IBDs, glomerulonephritis, Goodpasture’s syndrome, etc
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Anti-nuclear Ab
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directed to nuclear components; good screening for patients suspected of having SLE
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Cytoplasmic pattern
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lupus (anti-ribosomal P Ab), 1° biliary cirrhosis (anti-mitochondrial Ab), myositis (anti-Jo1 ab
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Nucleolar pattern
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SLE, SSc, & PM (anti-RNP Ab without anti-SM Ab); SSc (anti-U3 Ab); lcSSc (anti-Th ab
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Nuclear homogenous pattern
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SLE, drug-induced SLE, RA (anti-dsDNA Ab, anti-histone Ab)
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Nuclear speckled pattern
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lcSSc (anti-centromere Ab)
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Anti-phospholipid Ab
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related to biological false-positive VDRL (syphilis test) & to circulating anti-coagulant in SLE
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Anti-ribosomal P Ab
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related to hepatitis, nephritis, depression, & psychosis in SLE
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Anti-Ro Ab
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related to nephritis, photosensitivity, lymphopenia, purpura, vasculitis, & pneumonitis in SLE; presence in mother associated with congenital complete heart block (permanent) & neonatal lupus dermatitis in fetus (temporary)
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Anti-Scl-70 (topoisomerase 1) Ab
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associated with diffuse sclerosis
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Anti-Sm Ab
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associated with isolated CNS disease and nephritis in SLE
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Anti-U1RNP Ab
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related to myositis and Raynaud's phenomenon in SLE
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Rheumatoid factor
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IgM against Fc portion of IgG. Seen in RA, Sjorgren’s syndrome, scleroderma, polymositis, vasculitis and SLE
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