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6 Cards in this Set
- Front
- Back
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IgM
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largest, pentamer
10 FAB sites, 5FC sites Activates classical complement Only need one molecule to bind to b/c it is so big neutralizes toxins neutralizes infectivity of extracellular virus and bacteria 1st IG formed, DIAGNOSTIC TOOL In acute phase, generally monomer on mature B cells |
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IgG
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80% of all Ig
neutralizs toxins(ezymatic activity) neutralizes infectivity of extracellular virus and baceria Activates Classiscal Comp. Pathway Crosses the Placenta |
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IgA
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2 forms
monomer in blood (lot alot) dimer in secretions (sIgA) 4FAB 2FC with a J joining chain protects mucosal surfaces present in all secretions, saliva, tears, colostrium, breast milk, mucosal secretions |
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sIgA
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sIgA producing plasma cells migrate to all secretory and mucosal sites
interfers with attahcemtn and colonization neutralize infectivity of extracellular virus and bacteria neutrilizes toxins |
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IgE
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nearly all is blound to the surface of Mast cells and Basophils via its FC end
Mast Cells and Basophils are covered with IgE Mast cells release histamines b/c of IgE |
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IgD
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found ONLY on the surface of mature B cells as a receptor for Agn
FC end is attahced to B Cell FAB waits for antigen |
