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6 Cards in this Set

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IgM
largest, pentamer
10 FAB sites, 5FC sites
Activates classical complement

Only need one molecule to bind to b/c it is so big

neutralizes toxins

neutralizes infectivity of extracellular virus and bacteria

1st IG formed, DIAGNOSTIC TOOL

In acute phase, generally monomer on mature B cells
IgG
80% of all Ig

neutralizs toxins(ezymatic activity)

neutralizes infectivity of extracellular virus and baceria

Activates Classiscal Comp. Pathway

Crosses the Placenta
IgA
2 forms

monomer in blood (lot alot)

dimer in secretions (sIgA)

4FAB 2FC with a J joining chain

protects mucosal surfaces
present in all secretions, saliva, tears, colostrium, breast milk, mucosal secretions
sIgA
sIgA producing plasma cells migrate to all secretory and mucosal sites

interfers with attahcemtn and colonization

neutralize infectivity of extracellular virus and bacteria

neutrilizes toxins
IgE
nearly all is blound to the surface of Mast cells and Basophils via its FC end

Mast Cells and Basophils are covered with IgE

Mast cells release histamines b/c of IgE
IgD
found ONLY on the surface of mature B cells as a receptor for Agn

FC end is attahced to B Cell

FAB waits for antigen