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23 Cards in this Set
- Front
- Back
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What are the families of human DNA viruses?
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Parvovirus
Papovavirus Adenovirus Herpes virus Poxvirus Hepadnavirus |
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What is the capsid structure of human DNA viruses?
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All icosahedral except Poxvirus (complex)
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Which of the DNA viruses are enveloped?
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Herpes
Pox Hepadna |
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Which of the DNA viruses are naked?
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Parvo
Papova Adeno |
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Which of the DNA viruses are ssDNA?
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Parvo
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Which of the DNA viruses are dsDNA?
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Papova
Adeno Herpes Pox Hepadna (partially ds, circular) |
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Which of the DNA viruses replicate in the nucleus?
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Parvo
Papova Adeno Herpes Hepadna(?) |
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Which of the DNA viruses replicate in the cytoplasm?
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Pox
Hepadna(?) |
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Which of the DNA viruses use virion-associated polymerase?
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Pox
Hepadna |
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Describe characteristics of Poxviridae.
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Large, brick-shaped (dumbbell core) particles
Viral DNA replicates in cytoplasm, similar to cellular DNA but uses virus-coded enzymes Predilection for epidermal cells Complex membrane |
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Describe the transmission of Variola (Smallpox).
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Man is the only known host
Smallpox is inhaled then replicates in upper respiratory tract Internal and dermal tissues are seeded with the virus after two round of viremia |
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Describe the Level A procedures
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Rash assessment (CDC webpage)
Rule out chickenpox Specimen of choice is lesion material from pustules |
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How do you distinguish between chickenpox and smallpox?
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Smallpox - rashes on extremities/face (centrifugal)
Chickenpox - rashes on trunk |
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What is the importance of vaccinia virus?
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The basis for modern smallpox vaccine
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Describe the transmission of molluscum contagiosum.
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Pox virus
Transmitted by direct contact or fomites, especially in HIV patients and children Virus infects basal cell layr and replicates |
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Describe the presentation of molluscum contagiosum.
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Lesions are smooth, firm, shiny, flesh colored to pearly white hemispheric papules with umbilicated centers (dimples) confined to the skin and mucous membranes
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Describe characteristics of Herpesviridae.
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Enveloped icosahedral nucleocapsids
Latent or chronic infection Can be oncogenic |
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What are characteristics of Herpes simplex 1 (HSV-1)?
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Primary infections subclinical
Latency in ganglia of sensory nerves innervating affected area, which can be activated later Fever, blisters, keratoconjunctovitis, encephalitis |
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What are characteristics of Herpes simplex 2 (HSV-2)?
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Genital or perinatal primary infection
Latency in sacral ganglia which can be reactivated |
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What are characteristics of HSV replication in cells?
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Travel along microtubules of host cells (epithelial, neurons)
Budding (use host membrane for envelope) |
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What diseases does Varicella Zoster (VZV) cause?
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Varicella - Chickenpox
Herpes zoster - Shingles |
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What is the difference between chickenpox and shingles?
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Chickenpox - childhood primary disease, very contagious, passed by respiratory route, primary maternal varicella can cause defects in fetus
Shingles - reactivation of latent virus from posterior root of ganglia or cranial nerve roots, skin eruptions |
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Is there a vaccine for VZV?
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YES
Chickenpox - live, attenuated vaccine Shingles - Zostavax |
