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42 Cards in this Set
- Front
- Back
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What is the mechanism of the penicillins?
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Inhibition of the bacterial transpetidase
CIDAL |
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What is the mechanism of vancomycin?
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Inhibition of the joining of D-ala to D-ala in bacteria
CIDAL |
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What is the mechanism of daptomycin?
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Formation of a pore wihin the bacterial cell wall; depolarization
CIDAL |
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What is the mechanism of the cephalosporins?
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Inhibition of the bacterial transpeptidase
CIDAL |
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What is the mechanism of the carbapenems?
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Inhibition of the bacterial transpeptidase
CIDAL |
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What is the mechanism of clindamycin?
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Inhibition of bacterial elongation by binding to the 50S ribosome
STATIC |
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What is the mechanism of the macrolids?
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Inhibition of bacterial elongation at the 50S ribisome
STATIC |
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What is the mechanism of linezolid?
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Inhibition of formation of the bacterial initiation complex by binding to the 23S ribosomal complex
STATIC |
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What is the mechanism of chloramphenicol?
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Inhibition of bacterial protein synthesis by binding to the 50S ribosome
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What is the mechanism of the aminoglycosides?
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Binding to the bacterial 30S ribosome to:
Inhibit entry of aatRNAs Inhibit protein synthesis Inhibit mRNA reading CIDAL |
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What is the mechanism of the tetracyclins?
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Inhibition of bacterial protein synthesis by preventing aatRNA through binding to the 30S ribosome
STATIC |
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What is the mechanism of the quinalones?
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Formation of dsDNA breaks by binding to bacterial TopoisomeraseIV and DNA gyrase
CIDAL |
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What is the mechanism of Nitrofuratonin?
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When reduced, the molecule forms dsDNA breaks
CIDAL |
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What is the mechanism of metronidazole?
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When activated by pyruvate:ferrodoxin oxidoreductase, it forms dsDNA breaks in the DNA
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What is the mechanism of Fidaxomicin?
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Inhibition of the RNA polymerase of C. difficile
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What is the mechanism of Isoniazid?
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When activated by katG, it inhibits InhA, preventing mycolic acid in Tb
CIDAL |
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What is the mechanism of Rifampin?
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Inhibition of mycobacterial RNA polymerase
CIDAL |
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What is the mechanism of Pyrazinamide?
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Inhibition of the mycobacterial FASI
CIDAL |
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What is the mechanism of Ethambutol?
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Inhibition of the embB gene, inhibiting the polymerization of arabinin
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What is the mechanism of Streptomycin?
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Inhibition of Tb protein synthesis, entry of aaTRNAs, and mRNA reading by binding to the 30S ribosome
CIDAL |
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What is the mechanism of rimantadine/amantadine?
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Blocking of the M2 proton pump in influenza A --> prevention of acid-depended fusion of the virus
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What is the mechanism of zanamavir/oseltamavir?
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Inhibition of Influenza A and B neuramidase; virus can't be released from the cell
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What is the mechanism of Trimethaprim?
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Inhibition of DHFR
STATIC |
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What is the mechanism of the sulfonamides?
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Inhibition of dihydropteroate synthase
STATIC |
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What is the mechanism of amphotericin B?
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Binding to ergosterol in the fungal cell wall; forming a pore
FUNGICIDAL |
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What is the mechanism of 5-Flucytosine?
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After activation by cytadine deaminase, inhibition of thymadylate synthase
FUNGICIDAL |
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What is the mechanism of the azole antifungals?
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Competitive inhibition of lanosterol-14-alpha demethylase; can't synthesize ergosterol
STATIC |
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What is the mechanism of the echinocandins?
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Inhibition of the synthesis of beta-1-3 glycan, part of the fungal cell wall
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What is the mechanism of lamivudine?
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After activation by the HBV kinases, inhibition of HBV reverse transcriptase by being incorporated into the DNA
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What is the mechanism of tenofovir?
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NucleoTide analog; doesn't need activation by a kinase. Incorporation into the HBV (and HIV) nucleic acids, shutting down reverse transcription.
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What is the mechanism of interferon alpha?
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Inhibition of viral protein synthesis on all of the levels in HBV, HCV, and HPV
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What is the mechanism of ribavirin?
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In HCV:
Inhibition of purine biosynthesis Inhibition of RNA synthasis Inhibition of ATP metabolism |
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What is the mechanism of teleprovir or boceprevir?
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Inhibition of protease activity in Hepatitis C.
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What is the mechanism of acyclovir or ganciclovir?
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After activation by the Herpes kinases, inhibition of DNA synthesis by DNA polymerase
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What is the mechanism of action of cidofovir?
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No activation requred.
Inhibition of Herpes viral DNA synthesis by incorporation into the viral nucleic acids. |
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What is the mechanism of foscarnet?
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Inhibition of Herpes viral DNA synthesis by binding to the phosphate binding site on DNA polymerase
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What is the mechanism of action for AZT?
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After activation by HOST kinases, incorporation into HIV viral nucleic acids to halt RT activity
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What is the mechanism of efavirenz?
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Noncompetitive inhibition of RT in HIV
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What is the mechanism of lopinavir or rotiavir?
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Inhibition of HIV virus assembly by inhibition proteases
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What is the mechanism of enfuvirtide?
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Competitive inhibition of the binding of HR1 to HR2 on HIV surface; fuse with the cell
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What is the mechanism of Miravoc?
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Noncompetitive inhibition of binding of HIV to CCR5 on the host cell
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What is the mechanism of raltegravir?
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Inhibitor of HIV integrase
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