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42 Cards in this Set

  • Front
  • Back
What is the mechanism of the penicillins?
Inhibition of the bacterial transpetidase
CIDAL
What is the mechanism of vancomycin?
Inhibition of the joining of D-ala to D-ala in bacteria

CIDAL
What is the mechanism of daptomycin?
Formation of a pore wihin the bacterial cell wall; depolarization

CIDAL
What is the mechanism of the cephalosporins?
Inhibition of the bacterial transpeptidase

CIDAL
What is the mechanism of the carbapenems?
Inhibition of the bacterial transpeptidase

CIDAL
What is the mechanism of clindamycin?
Inhibition of bacterial elongation by binding to the 50S ribosome

STATIC
What is the mechanism of the macrolids?
Inhibition of bacterial elongation at the 50S ribisome

STATIC
What is the mechanism of linezolid?
Inhibition of formation of the bacterial initiation complex by binding to the 23S ribosomal complex

STATIC
What is the mechanism of chloramphenicol?
Inhibition of bacterial protein synthesis by binding to the 50S ribosome
What is the mechanism of the aminoglycosides?
Binding to the bacterial 30S ribosome to:

Inhibit entry of aatRNAs
Inhibit protein synthesis
Inhibit mRNA reading

CIDAL
What is the mechanism of the tetracyclins?
Inhibition of bacterial protein synthesis by preventing aatRNA through binding to the 30S ribosome

STATIC
What is the mechanism of the quinalones?
Formation of dsDNA breaks by binding to bacterial TopoisomeraseIV and DNA gyrase

CIDAL
What is the mechanism of Nitrofuratonin?
When reduced, the molecule forms dsDNA breaks

CIDAL
What is the mechanism of metronidazole?
When activated by pyruvate:ferrodoxin oxidoreductase, it forms dsDNA breaks in the DNA
What is the mechanism of Fidaxomicin?
Inhibition of the RNA polymerase of C. difficile
What is the mechanism of Isoniazid?
When activated by katG, it inhibits InhA, preventing mycolic acid in Tb

CIDAL
What is the mechanism of Rifampin?
Inhibition of mycobacterial RNA polymerase

CIDAL
What is the mechanism of Pyrazinamide?
Inhibition of the mycobacterial FASI

CIDAL
What is the mechanism of Ethambutol?
Inhibition of the embB gene, inhibiting the polymerization of arabinin
What is the mechanism of Streptomycin?
Inhibition of Tb protein synthesis, entry of aaTRNAs, and mRNA reading by binding to the 30S ribosome

CIDAL
What is the mechanism of rimantadine/amantadine?
Blocking of the M2 proton pump in influenza A --> prevention of acid-depended fusion of the virus
What is the mechanism of zanamavir/oseltamavir?
Inhibition of Influenza A and B neuramidase; virus can't be released from the cell
What is the mechanism of Trimethaprim?
Inhibition of DHFR

STATIC
What is the mechanism of the sulfonamides?
Inhibition of dihydropteroate synthase

STATIC
What is the mechanism of amphotericin B?
Binding to ergosterol in the fungal cell wall; forming a pore

FUNGICIDAL
What is the mechanism of 5-Flucytosine?
After activation by cytadine deaminase, inhibition of thymadylate synthase

FUNGICIDAL
What is the mechanism of the azole antifungals?
Competitive inhibition of lanosterol-14-alpha demethylase; can't synthesize ergosterol

STATIC
What is the mechanism of the echinocandins?
Inhibition of the synthesis of beta-1-3 glycan, part of the fungal cell wall
What is the mechanism of lamivudine?
After activation by the HBV kinases, inhibition of HBV reverse transcriptase by being incorporated into the DNA
What is the mechanism of tenofovir?
NucleoTide analog; doesn't need activation by a kinase. Incorporation into the HBV (and HIV) nucleic acids, shutting down reverse transcription.
What is the mechanism of interferon alpha?
Inhibition of viral protein synthesis on all of the levels in HBV, HCV, and HPV
What is the mechanism of ribavirin?
In HCV:

Inhibition of purine biosynthesis
Inhibition of RNA synthasis
Inhibition of ATP metabolism
What is the mechanism of teleprovir or boceprevir?
Inhibition of protease activity in Hepatitis C.
What is the mechanism of acyclovir or ganciclovir?
After activation by the Herpes kinases, inhibition of DNA synthesis by DNA polymerase
What is the mechanism of action of cidofovir?
No activation requred.

Inhibition of Herpes viral DNA synthesis by incorporation into the viral nucleic acids.
What is the mechanism of foscarnet?
Inhibition of Herpes viral DNA synthesis by binding to the phosphate binding site on DNA polymerase
What is the mechanism of action for AZT?
After activation by HOST kinases, incorporation into HIV viral nucleic acids to halt RT activity
What is the mechanism of efavirenz?
Noncompetitive inhibition of RT in HIV
What is the mechanism of lopinavir or rotiavir?
Inhibition of HIV virus assembly by inhibition proteases
What is the mechanism of enfuvirtide?
Competitive inhibition of the binding of HR1 to HR2 on HIV surface; fuse with the cell
What is the mechanism of Miravoc?
Noncompetitive inhibition of binding of HIV to CCR5 on the host cell
What is the mechanism of raltegravir?
Inhibitor of HIV integrase