Id 5T1: Neonatal Infections

Front 1

Focal seizures in neonates = HUGE tipoff for what disease

Back 1

herpes

Front 2

Neonatal herpes presents at what time?

Back 2

1st month of life; typically at week 2

Front 3

Summary Slides

• __% of febrile infants < 90 days will have serious bacterial infections

Group B strep more common in infants <___ days old

– Overall _________ incidence in era of aggressive screening and intrapartum abx

• E coli early onset sepsis has only _______ in low birth weight infants in the era of intrapartum ampicillin prophylaxis

• ________ resistance among gram negative organisms is increasing

Back 3

• 8% of febrile infants < 90 days will have serious bacterial infec,ons

Group B strep more common in infants < 28 days old

– Overall decreased incidence in era of aggressive screening and intrapartum abx

• E coli early onset sepsis has only increased in low birth weight infants in the era of intrapartum ampicillin prophylaxis

• Ampicillin resistance among gram negative organisms is increasing

Front 4

Summary Slides

• ________ and _______ is standard of care in young infants

• __________ and ____ can mimic serious bacterial infection in neonate

• Hepatis __ in neonate is more likely to be associated with chronic carrier state than in adult

• Neonatal ____ can present as rash, encephalitis or multisystem organ failure

– Empiric ________ while awaiting PCRs can prevent morbidity and mortality

Back 4

• Aggressive workup and empiric iv abx is standard of care in young infants

• Enterovirus and HSV can mimic serious bacterial infection in neonate

• Hepatis B in neonate is more likely to be associated with chronic carrier state than in adult

• Neonatal HSV can present as rash, encephalitis or multisystem organ failure

– Empiric acyclovir while awai,ng PCRs can prevent morbidity and mortality