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15 Cards in this Set
- Front
- Back
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Antibody structure |
Glycoproteins 2 heavy chains 2 light chains disulphide bond between chains hinge region - flexible |
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Antibody regions |
2 Fab (fragment antigen binding) - variable 1 Fc (fragment crystallisation) - attach Ab to cell |
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Immunoglobulins |
another word for antibodies - same Fc |
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Isotypes |
different Fc - this variation determines Ab class |
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Isotypes in decr conc. in blood |
G>A>M>D>E |
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Ag + Ab antigen + antibody binding is... |
- non covalent - therefore reversible - therefore strives to reach equilibrium |
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(Intrinsic) affinity |
- How strongly an antibody Fab region binds to antigen. - higher affinity = more effective |
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Bivalency |
- when more than one Fab binds to different antigen epitopes - bivalent = more effective |
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Avidity/Bivalent affinity of Antibody |
- Means functional affinity of Antibody When it comes down to it |
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Valency |
- No. of diff antigen epitodes one Antibody can bind |
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IgG |
- can cross between blood and tissue fluid - can cross placenta: immunity from mother to child - activate complement via classical pathway - Monomeric |
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IgA |
- Monomeric form in circulation - Dimeric form is primary defense for local infection - Dimer: 2 subunits joined by J chain and associated by secretory component chain |
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IgM |
- big so only seen in circulation not in tissues - first line defense - high avidity as pentamer, subunits low affinity - activate complement via classical pathway - Pentamer: 5 subunits held by J chain |
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IgD |
- very low conc in circulation - absent in memory cells - together with IgM on BCRs |
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IgE |
- low conc. in circulation - incr. if infected by parasitic worm - found bound to mast cells & basophils - Monomer |
