Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
88 Cards in this Set
- Front
- Back
|
Gent/Tobra Peak
|
5-10 mcg/mL
|
|
|
Amikacin Peak
|
20-30 mcg.mL
|
|
|
Gent/Tobra Trough
|
<2 mcg/mL
|
|
|
Amikacin Trough
|
< 5 mcg/mL
|
|
|
Tobra does/does not cover pseudo?
|
Does not
|
|
|
What is tobra usually used for?
|
Cystic fibrosis
|
|
|
When to take peak/troughs in traditional dosing?
|
Peak: 30 min after done with 30 min infusion
Trough: before 3rd dose |
|
|
What type of body weight do you use to dose aminoglycosides?
|
IBW
|
|
|
Amoxil, Moxatag
|
Amoxicillin
Fridge susp- improves taste Moxatag within 1 hr of finishing meal |
|
|
Augmentin
|
Amox + Clavulanate
Fridge susp |
|
|
Principen
|
Ampicilin
|
|
|
Unasyn
|
Ampicilin + sulbactam
|
|
|
Pen VK
|
Penicillin
Empty stomach Fridge susp |
|
|
Zosyn
|
Pip/Tazo
|
|
|
Timentin
|
Ticarcillin + Clav
|
|
|
PCNs DDI
|
Probenecid and Allpurinol increase concentrations
Seizures with accumulation |
|
|
1st Gen Cephs
|
Better + than -
Cefazolin Cephalexin |
|
|
Ancef, Kefzol
|
Cefazolin
|
|
|
Keflex
|
Cephalexin
|
|
|
2nd Gen Cephs
|
Better - than 1st gen with similar +
Cefaclor, Cefoxitin, Cefuroxime, Cefprozil |
|
|
Fox and Fur in ___ gen
|
2nd
|
|
|
Mefoxin
|
Cefoxitin
|
|
|
Ceftin, Zinacef
|
Cefuroxime
|
|
|
3rd Gen Cephs
|
Better - compared to 2nd and less + compared to 2nd
Cefdinir, Cefixime, Cefotaxime, Cefpodoxime, Ceftazidime, Ceftriaxone |
|
|
Omnicef
|
Cefdinir
|
|
|
Suprax
|
Cefixime
|
|
|
Claforan
|
Cefotaxime
|
|
|
Vantin
|
Cefpodoxime
|
|
|
Fortaz, Tazicef
|
Ceftazidime
|
|
|
Rocephin
|
Ceftriaxone
|
|
|
4th Gen Cephs
|
Best - and + similar to 1st gen
Cefepime |
|
|
Maxipime
|
Cefepime
|
|
|
5th Gen Cephs
|
MRSA, + with some -
Ceftaroline fosamil IV ONLY |
|
|
Teflaro
|
Ceftaroline fosamil
|
|
|
Carbapenems
|
+ / - , Anaerobes, NO Atypicals
Can decrease valproic acid conc |
|
|
Primaxin
|
Imipenem/Cilastatin
Seizures most common Cilastatin prevent degradation in kidney Avoid with ganciclovir |
|
|
Merrem
|
Meropenem
|
|
|
Invanz
|
Ertapenem
ERRK: not broad spectrum Does not cover pseudo/acinetobacter |
|
|
Doribax
|
Doripenem
|
|
|
FQs
|
+ / -, Some Atypical, NO Anaerobes
Preg Cat D (CI) Tendon rupture QT prolong |
|
|
4th Gen Cephs
|
Best - and + similar to 1st gen
Cefepime |
|
|
Maxipime
|
Cefepime
|
|
|
5th Gen Cephs
|
MRSA, + with some -
Ceftaroline fosamil IV ONLY |
|
|
Teflaro
|
Ceftaroline fosamil
|
|
|
Carbapenems
|
+ / - , Anaerobes, NO Atypicals
Can decrease valproic acid conc |
|
|
Primaxin
|
Imipenem/Cilastatin
Seizures most common Cilastatin prevent degradation in kidney Avoid with ganciclovir |
|
|
Merrem
|
Meropenem
|
|
|
Invanz
|
Ertapenem
ERRK: not broad spectrum Does not cover pseudo/acinetobacter |
|
|
Doribax
|
Doripenem
|
|
|
FQs
|
+ / -, Some Atypical, NO Anaerobes
Preg Cat D (CI) Tendon rupture QT prolong |
|
|
FQs AEs
|
Tendon rupture
Qt prolong Photosensitivity Crystalluria Hypo/Hyperglycemia GI Upset, HA, rash |
|
|
FQs DDIs
|
Antacids (2 hr before or 4-6 hr after)
Qt prolong drugs Probenecid/NSAIDs can increase levels |
|
|
Floxin
|
Ofloxin
|
|
|
Noroxin
|
Norfloxin
|
|
|
Cipro, Cipro XR, Proquin XR, Ciloxan opthalmic, Cetraxal
|
Ciprofloxacin
1A2 inhibitor |
|
|
Levaquin, Iquix and Quixin opth
|
Levofloxacin
|
|
|
Zymar opth
|
Gatifloxacin
|
|
|
Avelox, Vigamox opth
|
Moxifloxacin
No dose adj in renal imp |
|
|
Factive
|
Gemifloxacin
|
|
|
Macrolides
|
+ / -, Atypical, No Anaerobes
QT prolong 3A4 inhibitors (A/C/T) A/C: no Fridge E: Fridge |
|
|
Zitrhomax, Z-Pak, Zmax, Azasite opth
|
Azithromycin
Better Gram - No Fridge Zmax Azasite: Flip/Whip/Drip |
|
|
Biaxin, Biaxin XL
|
Clarithromycin
Better Gram + No Fridge Biaxin XL with food |
|
|
EES, Ery-tab
|
Erythromycin
Fridge Ab pain and cramping |
|
|
Tetracyclines
|
CI: children < 8
Preg Cat D |
|
|
Tetracyclines AEs
|
Photosensitivity
Teeth discolor 8 oz water Remain upright 30 min |
|
|
Vibramycin, Vibra-tab, Oracea, Doryx, etc.
|
Doxycyline
Oracea: 1 hr before of 2 hrs after meals Others with food decreases GI upset |
|
|
Minocin, Dynacin, Solodyn
|
Minocycline
|
|
|
Sumycin
|
Tetracycline
|
|
|
Tetracyclines DDIs
|
Cations 1-2 hrs before or 4 hrs after
Increase INR with warfarin Anticonvulsants decrease tetracycline Avoid with retinoic acids |
|
|
Sulfonamides
|
5:1 ratio
Mod inhibitor of 2C8/9 Caution with Warfarin No Fridge |
|
|
Sulfonamides AEs
|
GI upset
Crystalluria (8oz water) Photosensitivty Skin Rxn |
|
|
Bactriim, Septra, others
|
Sulfamethoxazole/Trimethoprim
|
|
|
Sulfonamides CIs
|
Pregnancy at term
Sulfa allergy Anemia due to folate deficiency |
|
|
Vancocin
|
Vancomycin
30 min/ 500 mg of drug infusion time Pneumonia trough: 15-20 Other trough 10-15 Time dependent killing |
|
|
Zyvox
|
Linezolid
MRSA, VRE faecium and some faecalis Myelosuppression MAOi (SSRIs, SNRIs, Tyramine, Alcohol) No Fridge |
|
|
Synercid
|
Quinupristin + Dalfopristin
MRSA & VRE faecium 3A4 inhibitor Phlebitis, inj site rxns Hyperbilirubinemia Arthalgias, Myalgias |
|
|
Cubicin
|
Daptomycin
MRSA & VRE faecium/faecalis Increase Dapto with Statins NOT FOR PNEUMONIA Diarrhea/Constipation Edema, chest pain, Increased CPK and myopathy |
|
|
Vibativ
|
Televancin
MRSA 3A4 inhibitor BBW: Fetal risk AE: Foamy urine, QT prolong, Taste, Red Man's Syndrome, N/V |
|
|
Azactam- IV, Cayston- inhaled for Cystic Fibrosis
|
Aztreonam
Covers Pseuod and - Can be used in PCN allergic |
|
|
Chloramphenicol
|
Rarely used due to AEs
Myelosuppression BBW + / -, Anaerobes, Atypicals |
|
|
Ketek
|
Telithromycin
+ / -, some Anaerobes, Atypicals 3A4 inhibitor CI: Myasthenia Gravis & pts allergic to MACs AE: QT Prolong, Visual disturbances, hep. failure |
|
|
Tygacil
|
Tigecycline
+ /-, VRE, Anaerobes, Atypicals Not good with PSEUDO Increase INR with Warfarin Preg D CI: < 8 yo AE: Photosensitivty, N/V/D, Raised LFTs |
|
|
Cleocin
|
Clindamycin
+ (not enterococcus) & Anaerobes BBW: Fatal Colitis AE: N/V/D, urticaria, rash |
|
|
Flagyl, Metrogel topical
|
Metronidazole
Anaerobes & Protozoa CI: 1st trimester XR on empty stomach AE: Disulfiram, Metallic taste, Furry/Enlarged tongue, Dark Urine, Peripheral neuropathy |
|
|
Tindamax
|
Tinidazole
Protozoa & Bacterial Vaginiosis Org AE: Like Flagyl, Disulfiram, Metallic taste, Dark Urine, Peripheral neuropathy, GI upset |
|
|
Xifaxin
|
Rifaximin
Traveler's Diarrhea Not systemically abs |
|
|
Monurol
|
Fosfomycin
3g in 3-4 oz water UTI AE: Diarrhea |
|
|
Macrobid, Macrodantin
|
Nitrofurantoin
Macrodantin/Macrobid not interchangeable Take with Food CI: CrCl < 60 & Preg at term |
