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14 Cards in this Set
- Front
- Back
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fxn of spleen
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1. protect against blood borne (not interstitial) pathogens
2. specific immune responses 3. production adn processing of opsonins (tufsin and properdin) |
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Et of splenomegaly
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1. Congestive (CHF, cirrhosis, thrombosis)
2. Infxn 3. Inflamm 4. Sequestration of RBC 5. Infiltrative, non-malignant 6. Maligancies (leukemias, lymphomas) |
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lab results in pts with splenomegaly
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-invading organisms
-toxic granulations, Dohle bodies, vacuoles in neutrophils - |
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fragmented erythrocytes
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overwhelming sepsis
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nucleated red cells + tear-drop shaped cells
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BM invasion
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immature white cells or blasts in periph blood smear
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hematologic malignancy
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most imp cause of functional hyposplenism
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sickle cell
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what are Howell Jolly bodies
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RBC inclusions on peripoheral smear
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loss of immunologic fxn due to asplenia/hyposplenia can lead to what?
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DEATH!
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result of asplenia/hyposplenia
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DEATH! due to overwhelming infxn: **Streo pneumo, H flu, N. men
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Sx of asplenia//hyposplenia
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fever, then rapidly evolves into septic shock (and DIC possibly)
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what can you do to prevent overwhelming infxn post-splenectomy?
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Antibiotic Chemoprophylaxis:
DOC=penicillin/amoxacillin |
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lab results of splenomegaly
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-toxic granulations
-Dohle bodies -vacuoles in neutrophils |
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hypersplenism
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splenomegaly + destruction of 1 or more ell lines in periph blood
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