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15 Cards in this Set
- Front
- Back
basophils?
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1.neutrotransmitters
2.mast cell precursor 3.vasoactive amines |
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NK cells?
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viral imm (b/c kill the whole cell, and viruses usually intracellular)
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process of hematopoiesis req:
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1.stem cell pool
2.hematopoetic cytokines 3.stroma (supportive environ) 4.nutrients |
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PHSC's (pluripotent hematopoietic stem cells) express what antigen?
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ONLY CD34 (this is lost as cells differentiate)
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what properties do PHSC's have?
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1.self renewal
2.differentiation |
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-what are the earliest sites of PHSC prolif and differentiation?
-when and where do they appear? |
blood islands
-appear at 6 wks in the yolk sac |
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what happens after blood islands? during what time period
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-cells migrate from yolk sac to liver and spleen, where organ hemotopoiesis occurs thru 15th wk gestation
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desc embryology of hematopoiesis
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A. 6 wks: blood islands (earliest site of PHSC prolif and differentiation) appear in yolk sac.
B. 6 wks-15 wks: PSCSs in liver and spleen (organ hematopoiesis) C. 15 wks: BM (primary site of blood cell production thru remainder of gestation and post-birth life) |
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what dio PHSC's arise from?
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mesenchymal tissue
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extramedullary hematopoiesis
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=heamtopoiesis outside the BM
-in times of stress (i.e. CML), liver and spleen become HUGE b/c they revert to blood-forming organs |
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what drives differentiation of PHSC's?
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hematopoietic cytokines (hormones that regulate blodo cell production)
AND many cytokines are promiscuous (act on >1 lineage at >1 level of hematopoiietic development, i.e. IL3) |
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what is leukoerythroblastic rxn?
what does this suggest? |
presence of immature WBC's and nucleated RBC's
-suggests infiltrative process in BM |
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tear-drop RBC's
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suggests infiltrative process in BM (metastatic tumor, fibrosis, granuloma)
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hypercellular BM and peripheral cytopenia
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myelodysplastic syndrome (a "premalignant" condition)
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first sign of BM failure
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pancytopenia
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