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24 Cards in this Set
- Front
- Back
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LT complications to Tx in Pt w/Hodgkins
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1.secondary malignancies
2.endocrine prob 3.pulm prob 4.cardiac prob |
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what are non-Hodgkin's lymphoma (NHL)
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heterogenous gorup of lymphoid malignancies
-arise from monoclonal prolifersation of a malignant cell of lymphoid origin either T-cell or B-cell |
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what causes NHL
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unknown
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NHL: stage at presentation=disseminated
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low-grade NHL
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NHL: histo="nodular"
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low-grade NHL
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NHL: clinical course=slower clinical course, multiple recurrences
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low-grade NHL
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NHL: response to Tx=exquisitely sensitive
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low-grade
NHL |
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NHL: not curable
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low-grade NHL
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NHL: "follicular"
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low-grade NHL
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NHL: "indolent"
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low-grade NHL
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NHL: "favorable"
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low-grade NHL
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NHL: stage at presentation=localized
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high-grade NHL
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NHL: histology="diffuse"
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high grade NHL
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NHL: rapid clinical course
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high grade NHL
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NHL: potential curable
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high-grade NHL
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NHL: "aggressive"
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high-grade NHL
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what is the primary subclassification and primary determinant of survival and potential for cure
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histologic classification (grade)
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how Tx low-grade NHL?
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most low-grade ppl have disseminated Dz: not curable with chemo! just give chemo with palliative intent
(a few ppl with low-grade lymphoma have localized stage at presentation: do radiation w/curative intent) |
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how Tx high-grade NHL?
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combination chemo: CHOP
(Cyclophosphamide, Adriamycin, Oncovin Prednisome) |
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how Tx HL?
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Stage 1-2: radiation
Stage 3-4: combo chemo |
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NHL: response to therapy=exquisitely sensitive
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low-grade NHL
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"favorable" NHL
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low-grade NHL
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"aggressive" NHL?
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high-grade NHL
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someone presents iwth lymphadenopathy
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in order:
1. CBC 2. Mono-test 3. if abnl cells in peripheral blood, anemia-->BM aspiration |
