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24 Cards in this Set

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  • Back
LT complications to Tx in Pt w/Hodgkins
1.secondary malignancies
2.endocrine prob
3.pulm prob
4.cardiac prob
what are non-Hodgkin's lymphoma (NHL)
heterogenous gorup of lymphoid malignancies
-arise from monoclonal prolifersation of a malignant cell of lymphoid origin either T-cell or B-cell
what causes NHL
unknown
NHL: stage at presentation=disseminated
low-grade NHL
NHL: histo="nodular"
low-grade NHL
NHL: clinical course=slower clinical course, multiple recurrences
low-grade NHL
NHL: response to Tx=exquisitely sensitive
low-grade
NHL
NHL: not curable
low-grade NHL
NHL: "follicular"
low-grade NHL
NHL: "indolent"
low-grade NHL
NHL: "favorable"
low-grade NHL
NHL: stage at presentation=localized
high-grade NHL
NHL: histology="diffuse"
high grade NHL
NHL: rapid clinical course
high grade NHL
NHL: potential curable
high-grade NHL
NHL: "aggressive"
high-grade NHL
what is the primary subclassification and primary determinant of survival and potential for cure
histologic classification (grade)
how Tx low-grade NHL?
most low-grade ppl have disseminated Dz: not curable with chemo! just give chemo with palliative intent
(a few ppl with low-grade lymphoma have localized stage at presentation: do radiation w/curative intent)
how Tx high-grade NHL?
combination chemo: CHOP
(Cyclophosphamide, Adriamycin, Oncovin Prednisome)
how Tx HL?
Stage 1-2: radiation
Stage 3-4: combo chemo
NHL: response to therapy=exquisitely sensitive
low-grade NHL
"favorable" NHL
low-grade NHL
"aggressive" NHL?
high-grade NHL
someone presents iwth lymphadenopathy
in order:
1. CBC
2. Mono-test
3. if abnl cells in peripheral blood, anemia-->BM aspiration