Icp Drugs, Vecuronium

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Neuromuscular Blocking Drugs

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Paralysis/Muscle Relaxation; Facilitate tracheal intubation, improve surgical working conditions, good for mechanical ventilation of lungs, treat laryngospasm; Classified/chosen according or whether Depolarizing (mimics ACh, binds receptor @ muscle and activates receptor) or Non-depolarizing (binds @ receptor and blocks ACh), duration of action (whether long, intermediate or short acting; duration also affected by liver/kidney disease so keep that in mind), speed of onset, side effects, & pathophysiology; Act by interupting transmission of nerve impulses at NMJ of muscles; review in ppt adverse effects of SUX); Note: Int= Intubation Dose, Inf= Infusion

Neuromuscular Blocking Drugs
Group 3

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Neuromuscular Blocking Drugs

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Neuromuscular-blocking drugs block neuromuscular transmission at the neuromuscular junction, causing paralysis of the affected skeletal muscles.
This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release, or by acting postsynaptically at the acetylcholine receptor.
While there are drugs that act presynaptically (such as botulin toxin and tetrodotoxin), the clinically-relevant drugs work postsynaptically.
Clinically, neuromuscular block is used as an adjunct to anesthesia to induce paralysis, so that surgery, especially intra-abdominal and intra-thoracic surgeries, can be carried out with fewer complications.
Because neuromuscular block may paralyze muscles required for breathing, mechanical ventilation should be available to maintain adequate respiration.
Patients are still aware of pain even after full conduction block has occurred; hence, general anesthetics and/or analgesics must be given to prevent anesthesia awareness.

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Vecuronium
Drug
(trade name)

Back 3

(Norcuron)

Neuromuscular Blocking Drugs
Group 3

Front 4

Vecuronium
Class

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Aminosteroid, ND

Neuromuscular Blocking Drugs
Group 3

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Vecuronium
Uses

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Paralysis

Neuromuscular Blocking Drugs
Group 3

Front 6

Vecuronium
[ Supplied ]

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10mg powder vial, reconst.
to 1mg/ml w/ 10cc sdH2O

Neuromuscular Blocking Drugs
Group 3

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Vecuronium
Dosing--card

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0.1mg/kg (0.08-0.12)

Neuromuscular Blocking Drugs
Group 3

Front 8

Vecuronium
Dosing--Stever

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Int same, Inf 1-2mcg/kg/min, Maint 0.01mg/kg

Neuromuscular Blocking Drugs
Group 3

Front 9

Vecuronium
Caution

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Renal/Hepatic Dysfunction(elim.
Via these routes), Peds/ Elderly (larger/smaller dose resp.)

Neuromuscular Blocking Drugs
Group 3

Front 10

Vecuronium
Notes

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onset 3-5 m
Duration: 20-35 min

Neuromuscular Blocking Drugs
Group 3