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12 Cards in this Set

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Opioids/Narcotics
Pain Relief; choose based on potency, onset/duration time and method of metabolization (keep byproducts and their toxicity in mind).
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Opioids / Narcotics
Group 4
Opioids
Any opium-containing substance that is produced naturally in the brain.
Similar in effect or properties to opium but not derived from opium.
An opioid is a chemical that works by binding to opioid receptors, which are found principally in the central nervous system and the gastrointestinal tract.
The receptors in these two organ systems mediate both the beneficial effects and the side effects of opioids.
The analgesic (pain relieving) effects of opioids are due to decreased perception of pain, decreased reaction to pain as well as increased pain tolerance.
The side effects of opioids include sedation, respiratory depression, and constipation.
Opioids can cause cough suppression, which can be both an indication for opioid administration or an unintended side effect.
Narcotics
Agents that benumb or deaden, causing loss of feeling or paralysis.
Something that soothes, induces sleep, relieves pain or stress, or causes a sensation of mental numbness.
Fentanyl
Drug
(trade name)
Fentanyl

Opioids / Narcotics
Group 4
Fentanyl
Class
Synthetic Opioid

Opioids / Narcotics
Group 4
Synthetic Opioid
An Opiod made artificially by chemical synthesis, especially so as to resemble a natural product
Fentanyl
Uses
Analgesia

Opioids / Narcotics
Group 4
Fentanyl
[ Supplied ]
50mcg/ml

Opioids / Narcotics
Group 4
Fentanyl
Dosing--card
1-2mcg/kg premed; 2-5mcg/kg during Ind.
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Opioids / Narcotics
Group 4
Fentanyl
Dosing--Stever
low dose 1-2mcg/kg, mod dose 2-20 mcg/kg, Inf 1-2mcg/kg/hr

Opioids / Narcotics
Group 4
Fentanyl
Caution
75-125x more potent than morphine

Opioids / Narcotics
Group 4
Fentanyl
Notes
VERY lipid soluble & protein bound, can do IV,transdermal or PO, Peak effect 3-5m, duration 30-60m, 75% undergoes 1st pass pulmonary uptake/metab., Hemodynamic stability(doesn't cause histamine release), Drug interactions (can dec.
inhalation/induction agent dose req'd), can cause postop depression

Opioids / Narcotics
Group 4