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28 Cards in this Set
- Front
- Back
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3 environmental triggers for SLE
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UVB light
drugs EBV |
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HLAs associated with SLE
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DR2
DR3 |
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___ deficiency is associated with SLE, specifically ___ (3)
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complement
C1q C2 C4 |
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in SLE, a bystander reaction causes ___ cells to present ___ to ____ cells via ___, accompanied by ___.
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APC
self antigens T cells MHC II B7 costimulation |
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in response to dual stimulation by APCs, T cells express ___, which they use to cause ____ cells to ____
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CD40L
B cells make auto Abs |
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3 types of lupus
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discoid LE
SLE drug-induced LE |
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discoid LE is aka
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subacute cutaneous LE
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malar rash is present in ___% of SLE. in contrast to ____, it doesn't cross ___.
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50
dermatomyositis nasolabial folds |
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discoid means ___. it may occur with or without ___. it may cause ___ (2)
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annular, scaly plaques
systemic LE scarring alopecia |
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SLE oral ulcers are caused by ___ and are not ___.
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vasculitis
painful |
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in contrast to RA, SLE arthritis has no ___
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erosion
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4 pulmonary SLE complications
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pleurisy
pleural effusion pneumonitis PAH |
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SLE acute pneumonitis must be differentiated from ___. it should be treated with ___ or ___.
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infection
methyl prednisolone endoxane |
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SLE cardiac manifestations
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pericarditis
myocarditis CAD |
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___ endocarditis is common in SLE. in SLE it mostly affects ___.
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libman-sacks
mitral valve |
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SLE cranial neurapthy usually affects ___.
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eyes
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the most serious manifestation of SLE
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lupus nephritis
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lupus nephritis occurs in ___% of SLE. when it occurs it is usually ___
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50
asymptomatic |
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SLE CBC finding
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pancytopenia
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___ is a high sensitivity test for SLE. ___ is a marker of disease activity
___ is a high specificity test for SLE. |
ANA
anti dsDNA anti Sm |
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first line treatment for cutaneous SLE
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antimalarials
topical GC |
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second line treatment for cutaneous SLE
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MTX
azathioprine |
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tx for discoid lupus (2)
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thalidomide
mycophenolate mofetil |
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SLE neuro drug
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IV CTX
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lupus nephritis drug
drug for severe nephritis |
CTX
pulse IV CTX |
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when pregnant mother is positive for SSA and SSB, baby is at risk for ___
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congenital heart block
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drug induced lupus is more common in men/women. primary Abs associated are ___
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men
anti histone |
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3 common drugs causing SLE
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procainamide
hydralazine anti-TNF |
