• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/53

Click to flip

53 Cards in this Set

  • Front
  • Back
2 kinds of localized scleroderma
morphea
linear scleroderma
in localized scleroderma there are no ___ (2)
systemic symptoms
auto Abs
4 kinds of systemic sclerosis
limited cutaneous SSc
diffuse cutaneous SSc
sine scleroderma
overlap syndrome
limited cutaneous SSc affects ___ (2), but diffuse cutaneous SSc affects those and ___ (2)
distal extremities
face
proximal extremities
trunk
overlap syndrome combines SSc with one of ____ (6)
RA
polymyositis
SLE
Sjögren
vasculitis
sarcoidosis
limited cutaneous SSc is called CREST syndrome which stands for
calcinosis
Raynaud's phenomenon
esophageal dysmotility
sclerodactylyl
telangiectasia
male:female ratio for SSc
1:8
age range for SSc
35-55
the most important auto Ab for SSc
anti SCL-70
SCL-70 indicates ___ disease with high likelihood of ___
diffuse
interstitial lung disease
____ is an Ab associated with LC SSc
anti-centromere
vascular damage in SSc is caused by excess ___, impaired ___ (2) synthesis, and activation of ___ (2)
ET-1 excess
PGI2
NO
vWF
adhesion molecules
T/F: Raynaud's phenomenon is present in all forms of SSc
true
T/F: Raynaud's phenomenon is sufficient for SSc dx
false
___ are pathognomonic for SSc
pitting scars
3 kinds of vascular injuries associated with SSc
pulmonary HTN (PAH)
scleroderma renal crisis
gastric antrum vascular ectasia (GAVE)
patients with GAVE are prone to ___
GI bleeds
in SSc there is overproduction and accumulation of ___ in ___ (2)
collagen
small vessels
tissue
collagen deposition is driven by ___, especially ___. fibroblasts respond by producing ___
inflammatory cytokines
IL-6
collagen 1, 3, 7
___ score grades how stiff a patch of skin is
Rodnan
___ is the main cause of death in SSc and is a diagnostic criterion
pulmonary fibrosis
pulmonary fibrosis can cause ___, which can cause ___ (2 cardiac effects)
PAH
RHF
VF
___ is needed to detect pulmonary fibrosis. in early stage it appears as ___, in late stage it appears as ___.
high res CT
ground glass
honeycombing
SSc with honeycombing appearance is reversible/irreversible
irreversible
in LC SSc, you can have PAH without ___. this is called ___.
interstitial fibrosis
primary PAH
in primary PAH SSc, HRCT is ___
almost normal
in both primary and secondary PAH, DLCO is ___. in primary PAH, FVC is ___, but in secondary it's ___.
low
normal
low
T/F: reduced DLCO in primary constitutes a V/Q mismatch
true
___ anemia is associated with SSc renal disease
microangiopathic hemolytic
renal disease is primarily associated with ___ SSc with ___ Abs
DC
anti SD70
GIT is involved in ___% of SSc
50-80
when liver is involved in SSc it's in the form of ___
primary biliary cirrhosis
___ is a skeletal criterion for SSc. ___ (2) may be present with it.
sclerodactyly
acro-osteolysis (fracture of distal phalanx)
clubbing
___ is very common in SSc but is not a criterion. ____ is often superimposed on it.
calcinosis
infection
the only major SSc criterion
DC SSc
3 minor SSc criteria
pitting scars
sclerodactyly
pulmonary fibrosis
to diagnose SSc, you need ___ major criterion or ___ minor criteria
1
2
2 Abs characteristic of mixed CT disease
ANA
anti RNP
Tx for raynaud's phenomenon (3)
warmth (wax)
prostacyclin
bosentan (ET1 blocker)
Tx for calcinosis (2)
debridement
antibiotics
Tx for GI
high dose PPIs
steroids and MTX are used in SSc to treat ___ (3)
skin
joints
myositis
MTX is an example of a ___
disease modifying anti rheumatic drug (DMARD)
PAH in SSc is treated with
bosentan
synthetic PGI2
slidenafil
oxygen
10 year survival for DC SSc
55%
muscle ___ but not muscle ___ is present in polymyositis
weakness
pain
T/F: fever may be present in polylmyositis
true
___% of polymyositis/dermatomyositis pts have malignancy
20
most important diagnostic for DM/PM is ___, specifically ___.
muscle enzymes
CK
5 muscle enzymes measured in DM/PM
AST
ALT
CK
LDH
aldolase
main treatment for DM/PM
high dose steroids
DMARDS
IVIG
DMARDs used for DM/PM
MTX
azathioprine
IVIG counterindication
IgA deficiency