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41 Cards in this Set
- Front
- Back
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___ is the main indicator for acute phase response
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ESR
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ESR mainly reflects ___ (2)
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Igs
fibrinogen |
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increased ESR in acute phase is due to ___ by ___
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masking of repulsive negative charges
acute phase proteins |
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insidious diseases commonly have ___ ESR
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normal
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normal ESR for men
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age/2
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normal ESR for women
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(age+10)/2
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hematological findings associated with high ESR
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anemia
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6 hematological findings associated with low ESR
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sickle cell
anisocytosis spherocytosis acanthocytosis microcytosis polycythemia |
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high room temp increases/decreases ESR
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increases
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CRP is more/less sensitive marker of inflammation than ESR
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more
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3 rheumatology immunological tests
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serum protein electrophoresis
complement level autoantibodies |
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complement is commonly decreased in ___ disease
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immune complex
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rheumatoid factor is ___. it is most commonly elevated in ___ (2).
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anti Fc of IgG Ig
RA sjögren |
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RF is moderately commonly elevated in ___ (4).
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SBE
SLE leprosy liver disease |
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T/F: RF is an IgG
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false: can be other isotypes
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anti CCP is ___. advantage over RF is ___.
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Abs against cyclic citrullinated peptides
greater specificity |
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ANA is present in ___% of SLE and ___% of drug-induced lupus
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95
100 |
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ANA is associated with ___ (6) non-lupus diseases
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hepatitis
systemic sclerosis Sjögren RA polymyositis DM |
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___% of normals are ANA positive
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8
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main manifestations of drug-induced lupus
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fever
serositis |
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SLE commonly has positive ___ and ___ Abs, but drug-induced lupus typically has ___.
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anti-DNA
anti-histone anti-histone |
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drugs causing drug-induced lupus
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procainamide
quinidine hydralazine phenytoin |
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anti-Sm is present in 30% of ___. this means it has low ___.
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SLE
sensitivity |
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MCTD is ___. it is the combination of ___ (3).
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mixed CT disease
SLE scleroderma polymyositis |
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____ is a marker for MCTD with ___% sensitivity.
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anti RNP
100 |
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___ is a marker for limited scleroderma with ___% sensitivity.
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anti centromere
80-90 |
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___ is a marker for diffuse scleroderma with ___% sensitivity.
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anti scl-70
10-20 |
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scl-70 is aka ___, which does ___.
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DNA topoisomerase I
DNA uncoiling |
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anti SS-A is a marker for ___ (4).
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SLE
neonatal lupus subacute cutaneous lupus sjögren |
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anti SSB is a marker for ___ (2)
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Sjögren
SLE |
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C-ANCA is Abs against ___. it is a marker for ___. sensitivity when disease is active is ___%, in remission ___%.
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PR3
Wegener's granulomatosis 90 30 |
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P-ANCA is Abs against ___. it is a marker for ___ (3).
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MPO
Churg-Strauss MPA GN |
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P-ANCA is more/less sensitive than C-ANCA.
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less
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HLA B-27 is a marker for ___ with ___% sensitivity. it has high/low specificity
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ankylosing spondylitis
90 low |
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because of ___, HLA is not used as a diagnostic criterion
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low specificity
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synovial fluid is plasma ___ with ___ saccharides, especially ___.
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transudate
high MW hyaluronans |
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4 indications for arthrocentesis
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monoarthritis
infection crystal-induced arthropathy trauma with effusion |
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synovial fluid is normally ___ colored. in hemarthrosis it is ___ or ___, and in inflammatory arthropathy ___.
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yellow
orange red white |
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viscosity of synovial fluid is usually high/low. incase of degradation it becomes more/less viscous.
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high
less |
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normally there are ___ cells/mm^3 in fluid
in non-inflammatory arthropathy there are ___ in inflammatory arthropath there are ___. |
<200
<2000 2000-50000 |
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5 causes of arthropathy with cells>25000
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septic arthritis
crystal-induced arthropathy reactive arthritis RA intra-articular hemorrhage |
