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23 Cards in this Set
- Front
- Back
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in OA excess ___ is deposited on the femoral head
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fibrocartilage
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microscopically, in OA there are increased ___ and decreased ___
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chondrocytes
proteoglycan |
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because of ____, patients only present with late stage OA
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cartilage is not innervated
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genetic factors are prominent in ___ OA
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primary
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2 scenarios for developing OA
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normal load, inferior biomaterial
excessive load, normal biomaterial |
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in OA there a strong/weak correlation between severity of symptoms and structural change
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weak
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in OA, symptoms are due to ___ rather than ___
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joint damage
inflammation |
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T/F: morning stiffness is absent in OA
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false: <50 min, though
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top 3 hand joints affected by OA in descending order of frequency
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DIP
thumb base PIP |
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swollen DIP is called ___. swollen PIP is called ___.
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heberden node
bouchard node |
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both ___ and ___ deviations are possible in OA
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ulnar
radial |
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OA knee deformity is usually ___, but can be ___. the patella is commonly ___.
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genu varum
genu valgus deviated laterally |
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osteophytes cause decreased ___ between ___ and ___
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fluid exchange
subchondral bone cartilage |
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2 kinds of OA of hip
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atrophic
hypertrophic |
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cartilage loss appears on X-ray as
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joint space narrowing
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bone formation appears on X-ray as (2)
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osteophytes
subchondral sclerosis |
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vascular engorgement with high bone turnover appears on X-ray as
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cyst
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disrupted trabecular architecture appears on X-ray as
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deformity
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best drug for OA management
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paracetamol
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3 experimental OA therapies
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blocking IL-1
blocking MMP blocking iNOS |
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___ is an IL-1 blocker
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diacerein
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5 in vitro effects of chondroitin sulfate
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prevents chondrocyte apoptosis
increased PG synthesis reduce protease effect antiinflammatory decreased bone destruction |
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T/F: glucosamine and chondroitin sulfate are statistically proven OA therapies
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false
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