Icm Pulmonology 06: Asthma

Front 1

macrophages recruit eosinophilis with ___ and T cells do it with ___ aka ___

Back 1

PAF
CCL5
RANTES

Front 2

___ stimulate eosinophil activation with ___ (3)

Back 2

T cells
IL-3
IL-5
GM-CSF

Front 3

T/F: LTs are more important in asthma than HA

Back 3

true

Front 4

6 LT effects in asthma

Back 4

increased release of tachykinins
vessel permeability
eosinophil recruitment
increasead mucus secretion
decreased mucus transport
smooth muscle contraction

Front 5

asthma is linked to > ___ genes

Back 5

100

Front 6

increased family size is associated with higher/lower asthma incidence

Back 6

lower

Front 7

frequent antibiotic use is associated with higher/lower asthma incidence

Back 7

higher

Front 8

___ phenotype is associated with protective immunity and ___ phenotype with asthma

Back 8

TH1
TH2

Front 9

___ phenotype is associated with western lifestyle

Back 9

TH2

Front 10

T/F: viral infections can trigger asthma

Back 10

true

Front 11

T/F: dry air has more dust mites

Back 11

false: fewer

Front 12

asthma attack has a peak at ___ caused by ___ and a later one at ___ caused by ___

Back 12

1 hour
bronchoconstriction
6 hours
inflammation

Front 13

asthma exacerbations are commonly ___. they may be triggered by ___

Back 13

nocturnal
exercise

Front 14

2 drugs associated with asthma

Back 14

beta blockers
NSAIDs

Front 15

NSAIDs cause asthma by ___

Back 15

favoring LTs over PGs

Front 16

margins of liver and spleen may be ___ in asthma

Back 16

depressed

Front 17

T/F: accessory respiratory muscle use occurs in asthma

Back 17

true

Front 18

2 cardio findings in asthma

Back 18

tachycardia
pulsus paradoxus

Front 19

facial symptom of asthma

Back 19

allergic shiner

Front 20

in young asthma patients allergy is present ___% of the time. in adults it's ___%.

Back 20

80-90
50

Front 21

2 CXR findings in chronic asthma

Back 21

hyperinflation
right middle lobe syndrome

Front 22

5 CXR findings in acute asthma

Back 22

hyperinflation
infiltrates
pneumothorax
pneumomediastinum
atelectasis

Front 23

right middle lobe syndrome is ___. on CXR it appears as ___.

Back 23

obstruction of right middle bronchus
irregular right border of heart

Front 24

T/F: scooping of flow/volume curve is present in asthma

Back 24

true

Front 25

in asthma PEFR and morning PEFR is ___

Back 25

lower

Front 26

in asthma ___ (3) are reduced, ___ (2) are high, and ___ is normal

Back 26

FEV1
FEV1/FVC
FEV25-75
FRC
RV
TLC

Front 27

in asthma, ___ increases by ___% after ventolin

Back 27

FEV1
15

Front 28

inflammation of airways causes upregulation of ___ (enzyme), which converts ___ to ___ (2)

Back 28

NOS
R
NO
citrulline

Front 29

2 kinds of asthma drugs ___.

Back 29

relievers
controllers

Front 30

relievers work on ___ symptoms, controllers on ___.

Back 30

acute
chronic

Front 31

controllers work on ___ (3) cells.

Back 31

macrophage
T cell
eosinophil

Front 32

3 relievers

Back 32

albuterol
terbutalin
ipratropium

Front 33

all of the relievers are ___s except for ___ which is a ___

Back 33

beta2 agonist
antimuscarinic

Front 34

6 kinds of controllers

Back 34

inhaled CS
CS
cromolyn
long acting beta2 agonists
LT modifiers
theophylline

Front 35

cromolyn is a ___

Back 35

mast cell stabilizer

Front 36

theophylline is a ___. its mechanism of action in asthma is ___.

Back 36

methylxanthine
unknown

Front 37

5 side effects of beta2 agonists

Back 37

muscle tremor
hyperglycemia
hypokalemia
increased lactate
hypocalcemia

Front 38

albuterol and terbutaline have ___ onset and ___ duration because they are ___

Back 38

fast
short
hydrophilic

Front 39

salmeterol has a ___ onset and ___ duration because it's ___

Back 39

slow
long
lipophilic

Front 40

formeterol has a ___ onset and ___ duration because it's ___

Back 40

fast
long
both hydrophilic and lipophilic (?)

Front 41

it's important to give ___ together with beta2 agonists

Back 41

ICS

Front 42

theophylline is metabolized in ___ by ___.

Back 42

liver
CYP

Front 43

T/F: theophylline works as an anti-inflammatory

Back 43

false

Front 44

theophylline has a ___ therapeutic index

Back 44

narrow

Front 45

2 effects of CS

Back 45

PLA2 inhibition
COX downregulation