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26 Cards in this Set
- Front
- Back
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65--75% of breast ca is ___ positive
15--20% of breast ca is ___ positive |
estrogen R (ER)
HER2 overexpression |
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HER2 is aka ___. it is homologous to ___. it is antagonized by ___ aka ___.
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ErbB2
EGFR trastuzumab herceptin |
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ER+ breast ca is indolent/aggressive, metastasizes to ___, happens to younger/older pts
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indolent
easy to treat areas older |
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2 kinds of estrogen blockade
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receptor blockade
aromatase inhibition |
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ER blockade is done with ___, which is a ___
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tamoxifen
SERM |
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most important prognostic factor in breast ca
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axillary LN involvement
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tumors in premenopausal women are more/less aggressive than in post
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more
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2 downsides to tamoxifen tx
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thromboembolism risk
uterine ca risk |
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premenopausal pts should get ___
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tamoxifen
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ER+ pts get ___ (2), and HER2+ pts get ___ (2). pts + for both get ___. pts - for both get ___.
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endocrine tx
chemo trastuzumab chemo all 3 chemo |
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3 3rd generation aromatase inhibitors
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anastrozole
exemestane letrozole |
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anastrozole is non___
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steroidal
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anastrozole is aka
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arimidex
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exemestane is aka
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aromasin
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letrozole is aka
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femara
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4 adverse effects with letrozole
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hot flashes
arthralgia muscle pain osteoporosis |
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letrozole is more/less effective for prolonging survival than tamoxifen, and is associated with more/less bone fractures
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more
more |
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standard tx is first ___, then ___
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tamoxifen
letrozole |
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3 main side effects of letrozole
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hypercholesterolemia
hot flashes night sweats |
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3 main side effects of tamoxifen
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hot flashes
hypercholesterolemia night sweats |
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tykerb is aka ___. it does ___.
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lapatinib
inhibits Y kinase activity of EGFR, HER2 |
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HER2 overexpression can be detected via ___
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FISH
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HER2 overexpression causes increased/decreased aggressiveness of breast ca
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increased
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HER2 signals via ___ (2) pathways. these are blocked by ___
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MAPK
PI3K lapatinib |
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____ aka ___ is an anti-angiogenic drug which targets ___.
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bevacizumab
avastin VEGF |
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top 3 bevacizumab side effects
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HTN
infection sensory neuropathy |
