Icm Neuro 05: Ms

Front 1

___ results from an acute immune attack on Schwann cells

Back 1

Guillain-Barre

Front 2

___ results from a chronic immune attack on Schwann cells

Back 2

chronic inflammatory demyelinating polyradiculopathy (CIDP)

Front 3

MS has ___ to ___ female predominance

Back 3

3
1

Front 4

pts presenting with unilateral visual defects probably have ___. this is txed with ___. another possible cause is ___, which is ___.

Back 4

optic neuritis
CS
amaurosis fugax
TIA of the retina

Front 5

Lhermitte's sign is ___ and indicates ___. it is common in MS.

Back 5

electrical feeling on bending neck forward
C-spine irritation

Front 6

4 courses of MS

Back 6

benign
relapsing/remitting
2' progressive
1' progressive

Front 7

relapses are caused by ___
progressive disease caused by ___.
recovery after a relapse is due to ___ (2)

Back 7

inflammation
neurodegeneration
plasticity
axonal sprouting

Front 8

___% of MS is benign

Back 8

10--15

Front 9

prophylactic tx is given if ___ attacks occur within ___ years

Back 9

2
2

Front 10

an MS relapse is defined as neuro symptoms lasting ___

Back 10

>24 h

Front 11

diet for MS (3)

Back 11

low Glc
low salt
antacids

Front 12

plasma finding in MS

Back 12

oligoclonal bands

Front 13

oligoclonal bands have ___% sensitivity but not in early disease

Back 13

90

Front 14

T/F: CT in MS is normal

Back 14

true

Front 15

IFNg causes ___ (2) in brain. ___ blocks it.

Back 15

MQ attack on myelin
additional T cell recruitment
IFNbeta

Front 16

3 kinds of IFNb

Back 16

avonex
betaferon
rebif

Front 17

___ is an injectable myelin analog which dilutes the immune rxn

Back 17

copaxone

Front 18

___ aka ___ is a mAb against ___.
it caused ___.

Back 18

natalizumab
tysabri
alpha4 integrin
PML

Front 19

there is commonly postpartum ___ of MS ___ after delivery

Back 19

exacerbation
3 months