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27 Cards in this Set
- Front
- Back
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T/F: mild cognitive impairment does not interfere with ADLs
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true
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T/F: MCI stage exists for AD
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false
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___% of MCI pts per year get dementia
___% eventually do |
10-15
50 |
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3 anatomic predictors of MSI-dementia progression
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entorhinal/hippocampal atrophy
cerebrovascular disease white matter lesions |
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5 psychological predictors of MSI-dementia progression
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low MMSE
impaired memory anxiety depression loss of insight |
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genetic predictor of MSI-demntia progression
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apo-E4
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T/F: memory impairment is required for AD dx
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true
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AD starts in ___ lobe
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medial temporal
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___ on MMSE is moderate dementia
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20
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___ is the most common ApoE allele. patients with ___ ApoE phenotype have a 90% probability of getting AD.
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epsilon3
epsilon4/epsilon4 |
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APP is ___. it is on chromosome ___.
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amyloid precursor protein
21 |
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2 other AD-related genes
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PS1
PS2 |
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T/F: tau can be imaged
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true
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AD may be dxed based on ___ in CSF
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Abeta
tau |
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functional scanning shows reduced perfusion in AD of ___ regions
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posterior temporo-parietal
posterior cingulate frontal |
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___ degeneration in AD causes ___ deficiency. this is treated with ___ (2).
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nucleus basalis of Meynert
ACh AChEI BuChEI |
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3 AChEIs
___ also inhibits BuChE |
donepezil
rivastigmine galantamine rivastigmine |
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___ is an NMDA antagonist used to prevent excitotoxicity in AD
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memantine
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2 potential AD therapies which have yet to show effectiveness
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gamma secretase inhibitors
anti-fibrillization agents |
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___ is the 2nd most common cause of dementia
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dementia with Lewy bodies
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LBs in DLB occur in ___ (3) regions
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paralimbic
basal forebrain mesial frontal |
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there is marked ___ deficiency in DLB
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cholinergic
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unlike AD, in DLB ___ is preserved
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recognition memory
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DLB has impairment of ___ (2)
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attention
visuo-spatial function |
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fronto-temporal dementia has a ___ onset. it commonly manifests as ___
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insidious
apathy |
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FTD may present with ___
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ALS
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2 histopath patterns in FTD
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tau accumulation
TAR accumulation |
