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18 Cards in this Set
- Front
- Back
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enzymes degrade gliadin to ___. this can't be degraded by enzymes but can be degraded by ___
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33mer
tissue transgluatminase (tTG) |
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deamidated gliadin is a powerful stimulator of ___ (2)
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HLA DQ2
HLA DQ8 |
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95% of celiac pts have HLA ___
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DQ2
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3 CNS symptoms of celiac
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ataxia
seizures depression |
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3 skin/mucosal symptoms of celiac
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dermatitis herpetiformis
aphthous stomatitis hair loss |
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T/F: celiac can cause Fe deficiency anemia
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true
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in a study, celiac caused Fe deficiency anemia to appear ___er and ___er
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earlier
for longer |
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in addition to Fe deficiency, celiac pts can have ___ deficiency
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folate
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menarche in celiac pts is earlier/later
menopause is earlier/later |
later
earlier |
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2 reproductive problems in men with celiac
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androgen resistance
sperm dysfunction |
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2 skeletal problems in celiac
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arthritis
osteopenia |
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liver problem in celiac
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cryptogenic hepatitis
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2 requirements for celiac dx
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abnormal small intestine mucosa on biopsy while eating gluten
full resolution of disease after withdrawal of gluten |
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4 lab studies for celiac
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antiendomysial Abs
anti tTG antigliadin Abs antireticulin Abs |
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antigliadin and antireticulin have Ig___ (2)
antiendomysial and anti tTG have Ig___ |
A
G A |
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tTG/EMA is more sensitive
tTG/EMA is more specific |
tTG
EMA |
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___ is a mandatory procedure for dx
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small bowel biopsy
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patients with untreated CD who don't refrain from gluten are at risk for ___ (2)
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T cell lymphoma
squamous cell ca |
