Icm Gi 10: Colorectal Cancer

Front 1

rectum is drained by ___ vein
rest of colon is drained by ___ vein.
this means colon cancers mostly go to ___.

Back 1

iliac
hepatic portal
liver

Front 2

layer most cancers arise from

Back 2

mucosa

Front 3

99% of CRC starts as ___

Back 3

polyp

Front 4

CRC is associated with ___ consumption

Back 4

red meat

Front 5

adenomas start at ___

Back 5

bottom of crypts

Front 6

DNA hypomethylation happens at transition to ___

Back 6

adenoma

Front 7

oncogene mutations happen at transition from ___ to ___

Back 7

adenoma
severe dysplasia

Front 8

___ (2) happen at transition from dysplasia to cancer

Back 8

allelic deletions
aneuploidy

Front 9

most colorectal adenomas are single/multiple, bigger/smaller than 1cm, and are tubular/villous

Back 9

multiple
bigger
villous

Front 10

the more adenomas removed, the greater the risk for ___

Back 10

future adenomas

Front 11

4 screening choices for low-risk pts

Back 11

colonoscopy
fecal occult blood
sigmoidoscopy
barium enema

Front 12

1 screening choice for high-risk pts

Back 12

colonoscopy

Front 13

2 findings for middle-time detected CRC

Back 13

rectal mass
blood in stool

Front 14

Duke's A CRC reaches ___

Back 14

submucosa

Front 15

Dukes B1 CRC reaches ___

Back 15

muscularis

Front 16

Dukes B2 CRC reaches

Back 16

through serosa

Front 17

Dukes C1 CRC reaches ___ (2)

Back 17

muscularis
LNs

Front 18

Dukes C2 CRC reaches ___ (2)

Back 18

through serosa
LNs

Front 19

Dukes D CRC reaches ___ (2)

Back 19

at least submucosa
liver

Front 20

CRC is most commonly diagnosed at Dukes ___

Back 20

B

Front 21

vertebral CRC metastases are most likely from ___

Back 21

rectum

Front 22

biomarker which corresponds with Dukes stage

Back 22

CEA

Front 23

top 3 complications of CRC surgery. of them, only ___ occurs in colon ca.

Back 23

anastomotic leak
impotence
bladder dysfunction
anastomotic leak

Front 24

3 tx for liver mets

Back 24

resection
ablation
chemo

Front 25

chemo is not performed for Dukes ___ CRC

Back 25

A

Front 26

___ always causes cancer before 40.

Back 26

FAP

Front 27

ocular symptom of FAP

Back 27

congenital hypertrophy of retinal pigment epithelium (CHRPE)

Front 28

oral symptom of FAP

Back 28

abnormal dentition

Front 29

skin symptom of FAP

Back 29

epidermal cysts

Front 30

bone symptom of FAP

Back 30

osteoma

Front 31

endocrine symptom of FAP

Back 31

thyroid tumor

Front 32

5 growths caused by Peutz-Jeghers

Back 32

GI hamartomas
nasal polyps
bronchial polyps
reproductive tract tumors
abdominal carcinomas

Front 33

oral symptom of Peutz-Jeghers

Back 33

mucocutaneous pigmentation

Front 34

Peutz-Jeghers is linked to chromosome ___

Back 34

19

Front 35

hamartomas in PJ syndrome are in ___ (3)

Back 35

stomach
small int
colon

Front 36

HNPCC causes cancer primarily in ___. cancers are single/multiple. it is a ___ trait. unlike FAP, tumors don't arise from ___.

Back 36

right colon
multiple
AD
adenomas

Front 37

skin symptom of HNPCC

Back 37

keratocanthoma

Front 38

3 urogenital tissues affected in HNPCC

Back 38

uroepithelium
endometrium
ovary

Front 39

3 preventive tx for CRC for low-risk group

Back 39

high fiber
Ca2+
low fat

Front 40

3 preventive tx for CRC moderate risk group

Back 40

antioxidants
Selenium
aspirin

Front 41

preventive tx for CRC for high-risk group

Back 41

NSAIDs

Front 42

carcinoids arise most commonly in ___. carcinoid syndrome-causing carcinoids arise most commonly in ___. carcinoids which metastasize arise most commonly in ___.

Back 42

appendix
ileum
ileum