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7 Cards in this Set
- Front
- Back
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define IBS |
At least 3 days/month for last 3 months Pain+bloating relieved by pooing Diarrhoea/Constipation episodes |
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Treatment for IBS - 3 kinds |
1.Lactulose/Loperamide - Symptomatic 2. Antispasmodic agents- antimuscarinics, mebevarine (GI SM relaxant) 3. Amitryptiline (TCA)- pain relief, anti-M, alters neuron sensitivity |
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TCAs possible side effect + solution |
Constipation |
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Crohn's disease |
IBD with pain and bloody diarrhoea anywhere from mouth-anus |
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Ulcerative colitis |
IBD with pain and bloody diarrhoea from rectum up to colon |
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Treatments for UC |
5-aminosalicylates (5-ASA): Sulphasalazine- metabolised to give 5-ASA and sulphapyridine Mesasalazine (5-ASA) - pH changes yield 5-ASA- due to acid-base buffer action 5-ASA inhibits leukotriene and PG formation |
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Treatment for Crohn's and UC |
Corticosteroids- used to induce remission Prednisolone anti-inflammatoru glucocorticoid Budesonide- less systemic S.E.s Azathriopine, Ciclosporin, Methotrexate are all immunosuppressants infliximab- MAB-TNF alpha for sever Crohn's |
