Ibhs 524 Exam 2 Lecture 7

Front 1

Chromaffin cells

Back 1

adrenal medulla --> EPI, NE

Front 2

enterochromaffin cells

Back 2

intestines --> SERT

Front 3

ECL- enterochromaffin like cells

Back 3

stomach --> intestine

Front 4

platelets

Back 4

release SERT

Front 5

mast cells, basophils

Back 5

release histamine

Front 6

prefronal cortex of macaque

Back 6

glutamate (90% synapse), GABA (10% synapse)

Front 7

Dopamine

Back 7

motivation (doer)

Front 8

histamine

Back 8

anticipation (high hopes)

Front 9

ACh

Back 9

acquisition

Front 10

NE

Back 10

escape (non participation)

Front 11

serotonin

Back 11

cessation (separation)

Front 12

mesocortical pathway

Back 12

MAM, increased (ADD, Alz, wanting)/decreased activity (HD, Alz, wanting)

Front 13

Nigrostriatal pathway

Back 13

inh posture, decrease activity (restless legs syndrome, parkinsons)

Front 14

tuberoinfundibular pathway

Back 14

decreaes PL from anterior pituitary; decrease activity (PL --> dec estroen --> osteoP/infertility

Front 15

dopamine periphery

Back 15

adrenal medulla, low dose (incr renal flow, diuresis), high dose (incr HR and SV, vasoC, antidiuresis)

Front 16

Amphetamines

Back 16

reverses transporters (efflux dop/NE, reuptake, incr dop/NE in brain)

Front 17

Cocaine

Back 17

inh transporters (inh reuptake, incr dop/NE in brain)

Front 18

Zyban

Back 18

inh transporters (dop only), inh reuptake, increase dop levels in brain

Front 19

why is zyban less addictive than cocaine?

Back 19

zyban more specific (not incr NE as much as cocaine), can compensate by creating more reuptake (less dop) not cocaine

Front 20

Dopamine receptors: D1-like (D1, D5)

Back 20

excitatory: agonism - movement, wanting, mood

Front 21

Dopamine receptors: D2-like (D2, D3, D4)

Back 21

inhibitory: autoreceptors (neg feeback), heteroreceptors (agonist: ing PL rel, antagonist muscle control, antagonist: inc PL secretion, decr motor control)

Front 22

Dopamine drugs

Back 22

Zyprexa (olanzapine) heteroreceptor antagonist: anti psychotic, inh sertonin release

Front 23

Histamine

Back 23

CNS (wakefulness), peripheral (WBCs, eating/WCL in stomach -acid, arousal)

Front 24

H1

Back 24

agonist (wakefulness, dilation, bronchocontriction), antagonist (claritin: low sedation/low entry to CNS)

Front 25

promethazine

Back 25

H1 antagonist to mus M5 receptor

Front 26

H2

Back 26

excitatory: agonist (rel HCl, erection), antagonist (tagamet - heartburn)

Front 27

H3

Back 27

inhibitory (autoreceptor): agonist (inh release of histamine -autoregulation)

Front 28

H4

Back 28

agonist: increased WBC chemotaxis

Front 29

ACh: brain

Back 29

nicotinic (excitatory, CNS agonist/dop rel/cigarette), muscarinic (excitatory, CNS agonist/short term memory)

Front 30

ACh: peripheral movement (PNS and SNS)

Back 30

ACh to nicotinic receptors (direct: sk mus mov't, AM sec; indirect: ACh to musca rec, NE/E to adrenergic)

Front 31

NE (SNS): brain

Back 31

incr alertness, Memory Attention LEarning (decr ADHD)

Front 32

NE (SNS): peripheral movement

Back 32

AM --> NE, E (incr fuels, breathing, HR, sweating, circulation)

Front 33

NE drugs

Back 33

cocaine, Amph, elavil (inh transporters - NE, serotonin: inh reup AND incr NE/Sert), straterra (inh NE only: inh reup AND incr NE in brain)

Front 34

Alpha 1

Back 34

excitatory: agonist: vasoC sudafed

Front 35

Alpha 2

Back 35

inhibitory: agonist: decreased NE release from brain and adrenal gland: catapres

Front 36

Beta 1

Back 36

excitatory: agonist dobutamine (heart failure), antagonist (heart inhibition - lopressor)

Front 37

Beta 2

Back 37

agonist (airway relex - albuterol)

Front 38

Beta 3

Back 38

agonist: lipolysis from fat cells

Front 39

Serotonin: CNS

Back 39

positive mood, sensory input, cessation of appetite/arousal, lung modulation.

Front 40

Dysregulation of heart/lung modulation of Serotonin in CNS

Back 40

SIDS

Front 41

Serotonin: peripheral movement

Back 41

GI irritant (EC cells - 85% of serotonin in GI, vomiting, IBS), damage b.v (vasoC, fibroblast)

Front 42

reversal of serotonin transporters

Back 42

efflux of serotonin from vesc or platelets, incre sert in brain (NMDA - positive mood, fenfluramine - loss appetite)

Front 43

inhibition of serotonin reuptake transporter

Back 43

incre sert in brain but not in plasma, antagonism (SSRI incre sert, for OCD/dep, paxil)

Front 44

what is therapeutic lag

Back 44

occurs in inhibition of reuptake transporter. The autoreceptors must 1st desensitize b/f the concentration of extracellular serotonin in the synapse can become elevated appreciably

Front 45

5HT1A receptor

Back 45

agonist: dec rel of glutamate (less anx - buspar), sub P (pain), ACh (less memories), incr cortisol (less dehydration), incr beta endorphin (less pain), more dop (more association with event), vasoD, incr PL/oxytocin

Front 46

5HT1B/1D

Back 46

decreased rel of dop (more PL), vasoC in CNS (imitrex)

Front 47

5HT2A

Back 47

excitatory: agonist (LSD), antagonist (zyprexa), vasoC, platelet aggregation

Front 48

5HT3

Back 48

excitatory: stimulate vomiting via rec on vagus nerve in GI and rec in brain that are accesible to circulating sero: antagonist: zofran

Front 49

5HT4

Back 49

excitatory: stimulate peristaltic contractions in GI tract