Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Treatment of IBD
|
Aminosalicylates
Glucocorticoids Azothioprine, 6-mercaptoprine Methotrexate Anti-TNF-Ab |
|
|
Aminosalicylates (sulfasalazine, pentasa)
|
C: AZO = sulfasalazine - 5-ASA + inert compound; mesalamine - formulated 5-ASA
M: anti-inflammatory + antibacterial (AZO compounds) or delivered to small/large bowel (mesalamine compounds) U: Topical, UC |
|
|
Glucocorticoids (predisone, prednisolone, budesonide, hydrocortisone)
|
M: reduces inflammation
U: short-term control T: hyperglycemia, fat distribution |
|
|
Azothioprine, 6-mercaptopurine
|
M: purine antimetabolites; immunosuppressive properties; delay in therapeutic effect
U: UC T: nausea, vomiting, bone marrow suppression, hepatotoxicity; leukopenia (when taken with allopurinol) |
|
|
Methotrexate
|
M: dihydrofolate reductase inhibitor; antimetabolite
U: CD T: bone marrow suppression, megaloblastic anemia, alopecia, mucositis |
|
|
Anti-TNF Ab (infliximab, adalimumab, certolimumab)
|
M: bind to soluble + membrane-bound TNF --> prevent binding of receptor
U: parenteral; acute + chronic treatment for pt who do not respond to other meds T: suppression of Th1 inflammatory response; Ab against drugs |
