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20 Cards in this Set
- Front
- Back
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PDGF accelerates
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deposition of provisional matrix
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TGF-B hastens
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deposition of collagen
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VEGF and FGF induce
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a florid angiogenic response
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major components of the extracellular matrix
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collagens
basement membranes elastic fibers fibronectin proteoglycans |
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type I collagen
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skin, bone, mature scars
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type 2 collagen
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major component of cartilage
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type 3 collagen
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embryonic and pliable tissues- wound healing first
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type 4 collage
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does not form fibers- basement membrane
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the remodeling process is controlled by the binding of
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fibronectin and ubiquitous collagenase inhibitors
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collagenase
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remodels collagen
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elastic fibers provide
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recoil
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fibronectin binds
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many molcules such as collagen, fibrin, proteoglycans, cell-surface receptors
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wound healing
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induction of an acute inflammatory response
regeneration of parenchymal cells synthesis of extracellular matrix proteins migration and proliferation of both parenchymal and connective tissue cells remodeling collagenization and maturation of wound |
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granulation tissue is
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the initial event in the repair of an injury and consists of richly vascular connective tissue which contains capillaries, young fibroblasts, and variable infiltrate of inflammatory cells
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this occurs primarily by the action of myofibroblasts
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contraction
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factors that influence wound healing
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type, size, and location of the wound
vascular supply infection- delays wound healing and leads to more granulation tissue and scarring movement- wounds over joints do not heal well radiation- ionizing radiation is bad, UV is good overall nutrition age hormones |
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complications of wound healing
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defective scar formation
excessive scar formation contraction |
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dehiscence is usually due to
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wound infection
malnutrition hypoxia with ulceration, usually due to inadequate vasculatiry in a skin flap |
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keloids
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over-exuberant production of scar tissue, which is primarly composed of type III collagen
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excessive contraction of a wound is known as
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contracture
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