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43 Cards in this Set
- Front
- Back
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types of cytokines
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Interleukins
Interferons Colony stimulating factors Growth factors Chemokines |
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cytokines are
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redundant, pleiotropic, synergistic and antagonistic
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cytokines act through
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specific cell surface receptors
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TNF-alpha is
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Pro-inflammatory
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TNF-alpha is produced by
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Neutrophil and Macrophage activation
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TNF-alpha causes
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acute phase protein synthesis
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acute phase protein
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proteins whose plasma concentrations increase or decrease in response to inflammation
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TNF-alpha stimulates
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apoptosis
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IL-1beta causes
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fever induction
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IL-1beta is redundant with
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TNF-alpha
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IL-12 functions to
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co-activate NK and NKT cells which produce IFN-gamma
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IL-12 induces
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Th1 cells
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IFN-gamma activates
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macrophages
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IFN-gamma induces
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TNF-alpha and IL1-beta
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IFN-gamma increases
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MHC-II
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IFN-gamma induces
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CD4+ Th1 cells
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IFN-alpha,beta co-activates
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macrophages
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IFN-alpha,beta is
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antiviral
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IFN-alpha,beta induces
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MHC-I
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IL-17 causes
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neutrophil infiltration and activation
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IL-2 causes
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B cell proliferation and J chain synthesis
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IL-4 causes
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class switching to IgG1, IgE
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IL-4 induces
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Th2 induction
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TGF-beta causes
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class switching to IgA
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IL-5 causes____ and blocks____
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class switching to IgA
Blocks switching to IgG3 |
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IL-6 causes
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plasma cell differentiation
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IL-2 is a growth factor for
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CD4+, CD8+ T cells
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IL-2 promotes differentiation of
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Th, CTL and NK cells
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IL-2 induces ______ and _____
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Treg cells
activation-induced cell death |
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IFN-gamma activates
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macrophages
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IFN-gamma increases _____and is responsible for
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antigen presentation and is responsible for Th1 cell polarization
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Lymphotoxin (LT) causes
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apoptosis
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cytokines of hematopoiesis
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CSF or -poietins
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Cytokines of hematopoiesis can be used for
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recombinant factors for therapy
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____ and ____ are pluripotent cytokines of hematopoiesis
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stem cell factor
IL-3 |
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erythropoiesis cytokine that promotes it
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EPO-erythropoieten
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Platelet formation is induced by this cytokine
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thrombopoietin
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stimulates myelopoiesis
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IL-5
G-CSF M-CSF |
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IL-5 stimulates ___ growth
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eosinophils
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G-CSF stimulates ____ growth
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neutrophil
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M-CSF stimulates ____ formation
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monocyte
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Cytokines that promote lymphopoiesis
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IL-7
IL-15 |
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IL-7 stimulates________
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T and B cell
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