Hypothalamic And Pituitary Hormones (Ch 37)

Front 1

A syndrome characterized by polyuria, polydipsia, and hypernatremia

Back 1

Central diabetes insipidus caused by inadequate vassopression

Front 2

Tocolytics

Back 2

Drugs used to inhibit preterm labor (oxytocin receptor antagonist atosiban; magnesium sulfate; nifedipine; B2 agonits)

Front 3

Somatropin

Back 3

Recombinant human GH, increases the production of IGF-1. Administered subcutaneous injection. SE: Scoliosis, edema, gynecomastia, intracranial hypertension, myalgia, arthralgia, carpel tunnel, increased CYP450 activity.

Front 4

Disease associated with short stature that can be treated with Somatropin?

Back 4

Turner's syndrome, Noonan syndrome, Prader-Willi syndrome

Front 5

Pegvisomant

Back 5

GH receptor antagonist approved from the treatment of acromegaly. Initiates cellular signaling cascades by dimerizing 2 GH receptors. Drug cross links the receptors but doesn't allow for activation.

Front 6

Mecasermin

Back 6

IGF-1 agonist (if patient is not responsive to exogenous GH). Preparation is bound with protein extending half-life, SC injection. SE: hypoglycemia, intracranial hypertension, increased liver enzymes.

Front 7

Octreotide

Back 7

Agonist of somatostatin receptors. T(X) for acromegaly, hormone secreting tumors, acute control of esophageal varices. SE: GI issues, gallstones, bradycardia, cardiac conduction anomalies

Front 8

Lanreotide

Back 8

*Longer acting than octreotide*
Agonist of somatostatin receptors. T(X) for acromegaly, hormone secreting tumors, acute control of esophageal varices. SE: GI issues, gallstones, bradycardia, cardiac conduction anomalies

Front 9

Follitropin alfa

Back 9

Agonist of FSH receptor. T(X) controlled ovulation hyperstimulation in women, and infertility due to hypogonadism in men. SC injection.

Front 10

Follitropin beta

Back 10

*different carbohydrate side chains than Follitropin alfa*
Agonist of FSH receptor. T(X) controlled ovulation hyperstimulation in women, and infertility due to hypogonadism in men. SC injection.

Front 11

Urofollitropin

Back 11

Human FSH purified from urine of postmenopausal women.

Front 12

Menotropins (hMG)

Back 12

an extract of urine of postmenopausal women that contains both FSH and LH activity.

Front 13

Leuprolide

Back 13

Agonist of LH receptor. T(X) induced ovarian suppression, controlled ovarian hyperstimulation central precocious puberty, advanced prostate cancer.

Front 14

Gonadorelin

Back 14

Synthetic human GnRH

Front 15

Histrelin

Back 15

GnRH analog

Front 16

nafarelin

Back 16

GnRH analog

Front 17

triptorelin

Back 17

GnRH analog

Front 18

Ganirelix & Cetrorelix

Back 18

Antagonist of GnRH receptors. Prevention of premature LH surges during controlled ovulation hyperstimulation. SC injection.

Front 19

Abarelix & Degarelix

Back 19

approved for advanced prostate cancer

Front 20

Bromocriptine

Back 20

Agonist of dopamine D2. Treatment of hyperprolactinemia and parkison's disease. SE: vasospasm and pulmonary infiltrates in high doses.

Front 21

Cabergoline

Back 21

*Ergot derivative, similar to Bromocriptine*
Agonist of dopamine D2. Treatment of hyperprolactinemia and parkison's disease. SE: vasospasm and pulmonary infiltrates in high doses.

Front 22

Drugs _____ cause hyperprolactinemia by blocking the inhibitory effects of endogenous ____ on cells that release prolactin.

Back 22

Block dopamine D2 receptors (Bromocriptine, Cabergoline), dopamine

Front 23

What older dopamine D2 receptor blockers used as antipsychotic drugs are most likely to cause hyperprolactinemia?

Back 23

Phenothiazines, haloperidol

Front 24

Drugs that can cause hyperprolactinemia (that are not anti-psychotic)?

Back 24

methyldopa (antihypertensive), amphetamines, tricyclics, opioids

Front 25

Anti-psychotic drugs that is less likely to cause hyperprolactinemia?

Back 25

Olanzapine

Front 26

Oxytocin

Back 26

agonist of oxytocin receptor. Induction and augmention of labor, control or uterine hemorrhage after delivery. SE: fetal distress, placenta abruption, uterine rupture, fluid retention, hypotension.

Front 27

Atosiban

Back 27

Antagonist of oxytocin receptor. Tocolysis for preterm labor. SC: Infant death rates (?)

Front 28

Desmopressin

Back 28

Agonist of vasopressin V2 receptor. T(X) pituitary diabetes insipidus, hemophilia A and von Willebrand disease. SE: hyponatremia.

Front 29

Vasopressin

Back 29

available for treatment of diabetes insipidus and sometimes used to control bleeding from esophageal varices.

Front 30

Conivaptan

Back 30

Antagonist of vasopressin V1a and V2 receptors. T(X) hyponatremia in hospitalized patients.

Front 31

Tolvaptan

Back 31

Selective for vasopressin V2 receptors.

Front 32

Hormones that act through JAK/STAT receptors?

Back 32

GH and Prolactin

Front 33

Hormones that act through GPCR?

Back 33

LH, FSH, ACTH, TSH