Hypothalamic And Pituitary Hormones

Front 1

Name the hypothalamus related drugs/hormones of the lecture.

Back 1

Sermorelin
Octreotide
Bromocriptine
Cabergoline

(SOB C)

Front 2

Name the anterior pituitary related drugs/hormones of the lecture.

Back 2

Somatrem
Somatropin
Pegvisomat
Mecasermin

(S SP M)

Front 3

Name the posterior pituitary related drugs/hormones of the lecture.

Back 3

Vasopressin
Desmopressin
Conivaptan
Oxytocin

Front 4

Therapeutic uses of GH preps (4).

(note: Mecasermin is not a GH prep)

Back 4

1)Short stature due to congenital/acquired GH deficiency (Pituitary dwarfism)
2) GH deficiency in adults.
3) Turner's syndrome (pre puberty)
4) AIDS related muscle wasting

Front 5

Mecasermin can be used to treat this, and GH preps are ineffective at treating it.

Back 5

Laron Dwarfism

(GH jak/stat pathway does not work effectively, so you need to give straight up rh IGF-1)

Front 6

Pegvisomat can be used to treat what? and why (MOA)?

Back 6

MOA: Pegvisomat is a GH receptor antagonist (so it will IGF-1 levels).
Use: Tx acromegaly (as adjuvant)

Front 7

Give 1st, 2nd, and 3rd line treatments for acromegaly.

Back 7

1st line = Octreotide
2nd line, add DA agonist
3rd line, add Pegvisomat.

Front 8

GH prep adverse effects in children include?

Back 8

1) Increased intracranial tension
2) Headache
3) Papilledema
4) Scoliosis
5) Diabetes mellitus

Front 9

GH prep adverse effects in adults include?

Back 9

1) Periperal edema
2) Arthritis
3) Arthralgia
4) Myalgia
5) Carpal tunnel syndrome
6) Diabetes mellitus

Front 10

Somatostatin analogs: thereapeutic uses:

Back 10

Uses:
1) Acromegaly
2) Prevention of Gigantism
3) Carcinoid syndrome
4) VIPoma, gastrinoma
5) Ruptured esophageal varices

Front 11

Adverse effects of somatostatin analogs:

Back 11

1) GI tract problems (abdominal cramps, diarrhea, malabsorption, steatorrhea)
2) Gall stones
3) Vitamin B12 deficiency
4) Cardiovascular problems (sinus bradycardia, conduction disturbances)

Front 12

Prolactin has suppressing effect on ( ) secretion.

Back 12

Gonadotropin (aka, decrease LH/FSH resulting in infertility in either sex)

(This can be a problem when you have prolactinemia (likely do to a prolactinoma)).

Front 13

How would you treat prolactinemia? (what drugs)

Back 13

Bromocriptine
Cabergoline (longer acting and probably used more often)

Front 14

Uses of oxytocin?

Back 14

1) Induce and augment labor after cervix has ripened
2) Control post-partum hemorrhage
3) Improve milk ejection - nasal oxytocin

Front 15

MOA of Vasopressin

Back 15

Agonist at V1 and V2 receptors

Front 16

V1 = what type of receptor
V2 = what type of receptor

Back 16

V1 = Gq = vasoconstriction
V2 = Gs = aquaporin inserter (antidiuretic effect)

Front 17

Uses of Vasopressin

Back 17

1) Advanced cardiac life support
2) Ruptured esophageal varices

Front 18

Uses of Desmopressin

Back 18

1) Neurogenic DI (doc)
2) Von Willibrand Disease and Hemophilia A (PO or IV)
3) Enuresis (bed wetting, use nasal spray)

Front 19

What drugs would you use to treat SIADH?

Back 19

Conivaptan
Demeclocycline

Front 20

What are some broad causes of SIADH? (3)

Back 20

1) Drug-induced
2) CNS disorder
3) Paraneoplastic syndrome (small cell carcinoma of lung)

Front 21

Name some drugs that can induce SIADH:

Back 21

1) Carbamazepine
2) Chlorpropamide
3) vinca alkaloids