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36 Cards in this Set
- Front
- Back
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reduced synthesis of globin
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thalassemia
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what is a sideroblast
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abnormal RBC precursor unable to incorporate iron into hemoglobin
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causes of hypochromic microcytic anemia
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iron deficiency
thalassemia |
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clinical signs of iron deficiency anemias
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pica
koilonychia (concavity of nails) gastritis |
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toxic accumulation of iron
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hemochromatosis
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major storage form of iron that is readily released for heme synthesis
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ferritin
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long term storage form of iron
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hemosiderin
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storage form of iron that stains with prussian blue stain
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hemosiderin
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carrier protein of iron
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transferrin
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iron absorption
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gastric acidity reduces Fe+3 to Fe+2 (ferrous form)
Fe+2 absorbed in duodenum oxidized to Fe+3 in blood and taken up by transferrin |
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alterations of the duodenum that can result in iron absorption impairment
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chrons
celiac disease |
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total iron binding capacity is ___ in iron deficiency anemia
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increased
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what is TIBC
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Fe concentration needed to saturate transferrin
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unsaturated binding capacity is ____ in iron deficiency anemia
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increased
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what is free erythrocyte protoporphyrin
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RBC constituent that accumulates in iron deficiency
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FEP in thalassemia
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normal
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total body iron in sideroblastic anemia
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increased
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acquired sideroblastic anemia can be secondary to the consumption of what
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alcohol, lead
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what is plumbism and what are the sx
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lead poisoning
mental conc disorders low IQ impaired development |
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basophilic stippling
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abnormal iron metabolism
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ferritin levels in anemia of chronic disease
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increased
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serum iron levels in anemia of chronic disease
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decreased (sequestered into MACs)
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TIBC in anemia of chronic disease
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decreased
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FEP in anemia of chronic disease
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increased
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cytometric classification of anemia of chronic disease
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normochromic normocytic
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reticulocyte count in anemia of chronic disease
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decreased CORRECTED count
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viruses that can suppress BM
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HIV-1
parvovirus |
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red cell acanthocytes
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anemia assx with liver disease
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iron storage form that is water soluble and does not stain
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ferritin
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platelet levels in IDA if patient is bleeding
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increased (compensatory rise in platelets due to blood loss)
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normal transferrin saturation
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30%
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how to differentiate between IDA and anemia of chronic disease
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IDA: TIBC increased
ACD: TIBC decreased |
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first thing to measure in IDA
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ferritin
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how does free erythrocyte protoporphyrin distinguish between IDA and thalassemia
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IDA: FEP increased
thalassemia: FEP decreased |
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what causes anemia of chronic disease
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cytokines released from chronic disease cause sequesteration of iron in MACs and decreased availability to progenitor cells
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classification of anemia of chronic disease
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normochromic normocytic (unless long standing, it becomes microcytic)
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