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13 Cards in this Set
- Front
- Back
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Type 1 Hypersensitivity reaction
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RAPID HYPERSENSITIVITY REACTIONS
anaphylaxis=vessel dilation, dc C/O, bronchoconstriction IgE First and Fast its preformed and very quick |
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Type 2 Hypersensitivity reaction
what does it lead to? |
CYTOTOXIC REACTIONS
body makes special autoantibodies directed against self-cells. IgM and some IgG Antibody and complex lead to membrane attack complex 2= cy-2-toxic |
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Type 3 Hypersensitivity reaction
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IMMUNE COMPLEX REACTIONS- 3 things stick together: antigen, antibody and comliment
Excess antigens cause immune complexes to form in the blood. These circulating complexes usually lodge in small blood vessels Kidneys, skin, joints IgG |
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Type 4 Hypersensitivity reaction
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DELAYED HYPERSENSITIVITY REACTIONS
Reactive cell is the T-lymphocyte (T-cell) Local collection of lymphocytes & macrophages cause edema, induration, ischemia, & tissue damage |
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Example of type 1 hypersensitivity reaction
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anaphylaxis
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Example of type 2 hypersensitivity reaction
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Hemolytic anemia
Myasthenia gravis Goodpastures syndrome Thrombocytopenic purpura Hemolytic transfusion reactions |
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Example of type 3 hypersensitivity reaction
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Rheumatoid arthritis
Lupus Vasculitis |
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Example of type 4 hypersensitivity reaction
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Positive purified protein derivative(PPD
Contact dermatitis Poison Ivy Insect stings Transplant rejection Sarcoidosis |
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Example of type 5 hypersensitivity reaction
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Graves disease
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fever, urticaria, arthralgias, lyphadenopathy 5-10 days after trimethoprim exposure
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SERUM SICKNESS
an immune complex disease (type III) which antibodies to the foriegn protiens are produced. THey are deposited in membranes where they fix complement(leading to tissue damage) |
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serum sickness: what is there a decrease in in the labs?
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C3 levels
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Intradermal injection of a antigen produces edema and necrosis
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Arthus reaction!
its an activation of complement and it forms antigen complexes in the skin. |
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What type of hypersensitivity is a granuloma?
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type IV- delayed. IT has sensitized t lymphocyes and release INF-gamma causing tons of macrophages(CD 14) to show up
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