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37 Cards in this Set

  • Front
  • Back
What is the mechanism of the antibody-mediated type II Rxn
IgG and IgM Abs against cells and tissue
What is the mechanism of a type III Rxn?
Immune complex formation of IgG and IgM to circulating Ag
Examples of Type III Rxns

Poststrep glomerulonephritis
Arthus Rxn
Polyarteritis nodosa
Serum sickness
Mechanism AND presentation of Serum sickness
Caused by drugs - Ab to foreign Ag form immune complexes and are deposited in membrane where they fix complement.
Fever,urticaria, proteinuria, arthralgia, and lymphadenopathy 5-10 days after exposure to Ag
Mechanism of Arthus Rxn and Clinical presentation
Intradermal injection of Ag induces Ab and produces local Ab-Ag mediated Rxn.

Local pain and edema at site
Examples of Arthus Rxn?
Hypersensitivity pneumonitis, thermophilic actinomyces
Mechanism of RA Type III rxn?
IgM to IgG causing immune complex formation, activation of comlement, attracting PMNs, which release enzymes
What are the Type II Noncytotoxic hypersensitivity rxns?
Myasthenia gravis - Ab against ACH receptors in the postsynptic membrane

Graves Dz- Ab mediated stimulation of TSH receptors causing hyperthyroidism followed by hypothyroidism

Type II DM - Ab inhibit binding of insulin manefesting as Hypergly and DKA
What are the type II cytotoxic hypersensitivity rxns?
Autoimmmune hemolytic anemia
Transfusion reaction
Goodpasteurs syndrome
Autoimmune Thrombocytopenic purpura
Neonatal EBF
How does erythroblastosis fetalis occur?
RhD- Mother has baby w/RhD+ father and the fetus is RhD+. RhD+ IgG made when maternal and fetal blood come in contact. If mother isn't Tx at next pregnancy and has an RhD- fetus, the RhD+ IgG will cross the placenta and react with the fetal Rh+ RBCs
How do you prevent Erythroblastosis fetalis?
RhD- mother is given RhoGAM at 28wks gestation and again 72hrs after birth.
This anti-RhD Ab should also be given to any RhD- mother following any termination of pregnancy.
Difference between type II Noncytotoxic and Type II cytotoxic rxn in terms of Ab, compliment, and Effector cells
IgG, No compliment activation or ADCC, No effector cells

IgG and IgM, Compliment activation, PMN, Macro, NK
What are examples of Type IV Rxn?
Hashimoto thyroiditis
Contact dermatitis
Peripheral neuritis - ascending paralysis
IDDM (Type I)
Guillan-Barre - Ascending paralysis, peripheral nerve demylination
Mechanism of Type IV Rxn
Sensitized T cells (CD4 Th1 or CD8) encounter Ag - activated and release IFN-g (activate Macro) and TNF (induce inflammation)
Occurs 48-72hrs
What type of infections do you see T-cell mediated tissue injury due to a type IV rxn?
Chronic Intracellular pathogens
What are the mechanims by which infections trigger AI response?
1. Bystander activation - the recruitment of immune response may stimulate T cells that are not specific for the pathogen.
2. Molecular mimicry - Ag of microbes mimic or cross-react with self which causes the Abs made to the foreign to also recognize self
3. Exposure of sel-Ag that are normally concealed from the immune system (i.e. Goodpasteurs syndrome).
HLA subtype linked to RA?
HLA subtype linked to IDDM?
HLA subtype linked to MS?
HLA subtype linked to SLE?
HLA subtype linked to Celiac?
Dz linked to HLA B27
Ankylosing Spondylitis
Dz linked to HLA DR5?
Pernicious anemia
Hashimoto thyroiditis
Disorder associated with ANA?
Disorder associated with Anti-dsDNA, Anit-Sm
Specific for SLE
Disorder associated with Anti-histone
Drug-induces SLE
Disorder associated with Anti-IgG
Disorder associated with c-ANCA?
Vasulitis i.e. Wegners
Disorder associated with p-ANCA
Vasculitis i.e. microscopic polyangitis
Disorder associated with Anticentromere Ab?
Disorder associated with Anti-Scl-70 Ab?
Scleroderma (diffuse)
Disorder associated with Antimitochondrial Ab?
Primary biliary cirrhosis (PBS)
Disorder associated with Antiggladin Ab
Disorder associated with Anti-basement membrane
Goodpasteur's sybdrome
Disorder associated with Anti-epithelial Ab?
Pemphigus vulgaris
Disorder associated with Antmicrosomal Ab?
Hashimoto's thyroiditis
Disorder associated with Anti-Jo-1 Ab