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29 Cards in this Set

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VLDL compose __ % of total blood cholesterol and most of the _______ measured
15-20; triglycerides
LDL contain __ % of total blood cholesterol, half of which are taken up by the _____ and ____ from circulation and the other half are taken up by _______
60-70; liver; removed; peripheral cells (including heart and vascular)
HDLs help in _____ of cholesterol from the ______ to the _______
transport; peripheral cells; liver
7 categories of anti-hyperlipidemics
Bile acid resins (BAR)
Fibric Acid Derivatives
HMG-CoA reductase inhibitors
Cholesterol absorption inhibitors
Fish oils
Bile acid resins (BAR) MoA
Binds bile acid, which are precursors to cholesterol (in the GI tract), preventing reabsorption
Clinical Ix for BARs?
Used for LDL reduction; no effect on triglycerides
BARs agts?
Cholestyramine & colestipol
Constipation, diarrhea, nausea, flatulence
Sig drug interactions of BARs?
Bind to many drugs in gut (admin 1 hr prior or 4 hrs after)
Nicotinic Acid (Niacin) MoA?
Inhibits release of free fatty acids from adipose -> decreased rate of lipoprotein synthesis
Nicotinic Acid (Niacin)clinical Ix?
Moderate reduction in LDL and moderate increase in HDL
Cx for Nicotinic Acid (Niacin)?
liver disease, peptic ulcers, & EtOH abuse
Fibric Acid Derivatives (Fibrates) MoA?
Elimination of triglyceride (TG) rich particles; helps w/ LDL & HDL moderately
Fibric Acid Derivatives (Fibrates) avail agts?
gemfibrozil & fenofibrate (both have "fibr" in their names)
Cx of Fibric Acid Derivatives (Fibrates)?
Severe hepatic or renal dysfunc
AEs of Fibric Acid Derivatives (Fibrates)?
N/V, abd pain, muscle weakness
D-D interactions of Fibric Acid Derivatives (Fibrates)?
W/ statins, increases risk of myopathy
All HMG CoA Reductase Inhibitors are:
HMG CoA Reductase Inhibitors (statins) is most effective agent for:
LDL reduction; has moderate effect on HDL and TG
PKs & PDs of HMG CoA Reductase (statins) Inhibitors:
Dose dependent LDL reductions

Hepatically metabolized through 3A4 & 2C9 [1 exception]

Highly protein bound

Relatively short 1/2 lives w/ 2 exceptions
1/2 life exceptions for HMG CoA Reductase Inhibitors (statins)?
ator- and rosu- (longer)
Metabolism exception for HMG CoA Reductase Inhibitors (statins)
prava- (renal elim)
Sig D-D interactions:
Cholestyramine (BAR) may decrease absorption

Inhibitors of 3A4 and 2C9

Displacement (resulting in more free [active] drug)
Cholesterol Absorption Inhibitors MoA?
Inhibits chol. absorption by the small intestine
Cholesterol Absorption Inhibitors clinical Ix?
LDL reduction
Cholesterol Absorption Inhibitors agt?
Cholesterol Absorption Inhibitors Cx?
Active liver disease
Persistent elevation of liver enzymes
Why aren't anti-oxidants used?
Insufficient evidence
Fish Oil use:
Secondary prevention in polytherapy in pts with increased non-HDL issues

SE is diarrhea