Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
what are the 3 sources of cholesterol for the liver?
|
de novo synthesis
cholesterol absorbed by small intestine lipoproteins circulating in blood |
|
|
what is the rate limiting enzyme involved in the synthesis of cholesterol?
|
HMG CoA reductase
|
|
|
HMG CoA reductase inhibitors
|
ends in statin
|
|
|
HMG CoA reductase inhibitor prevents the productiong of?
|
mevalonate and then cholesterol
|
|
|
MOA of HMG CoA reductase inhibitor
|
upregulate LDL receptor to remove LDL from blood circulation
|
|
|
what effects will statin have on triglycerides?
|
modest reduction
|
|
|
what effects will statin have on LDL?
|
large reduction
|
|
|
the greatest LDL lowering effect is seen at the usual starting dose of a statin True or False
|
True
|
|
|
Pravastatin is metabolized by P450 system true or false
|
false
|
|
|
which two statin drugs have longer half life?
|
atorvastatin and rosuvastatin
|
|
|
when is hepatic cholesterol synthesis maximal at day or night?
|
night, between 12 to 2 am
|
|
|
should statin be taken at night or day?
|
night (before bed)
|
|
|
HMG CoA reductase inhibitor SE
|
rhabdomyolysis
|
|
|
Fibrates (especially gemfibrozil)
Niacin (rarely) CYP3A4 inhibitors Cyclosporine Azole antifungals (ketoconazole) Erythromycin Grapefruit juice (inhibit gut wall CYP3A4) |
drug interaction of HMG CoA reductase inhibitor
|
|
|
contraindications of HMG CoA reductase inhibitor
|
Active hepatic disease
Pregnancy and lactation Fetus requires cholesterol to develop cell membranes during growth |
|
|
bile acid binding resin agents
|
Cholestyramine (Questran, Locholest, Prevalite)
Colestipol (Colestid) Colesevelam (Welchol) |
|
|
MOA of bile acid binding resin
|
reduce bile recirculation
increase for bile synthesis upregulate LDL remove LDL from blood |
|
|
would you combine statin and bile acid binding resin?
|
yes
|
|
|
Would cholestyramine be indicated for the treatment of hypertriglyceridemia?
|
NO
|
|
|
do bile acid binding resin agents come in tablet and powder forms?
|
Yes
|
|
|
what is the rationale for taking bile acid binding resin before meals?
|
eating stimulate bile acid synthesis and release
|
|
|
Ezetimibe (Zetia)
|
cholesterol absorption inhibitor
|
|
|
MOA of ezetimibe?
|
decrease cholesterol delivery from the intestine to the liver
|
|
|
what does ezetimibe affect the clearance of cholesterol from the blood?
|
increases
|
|
|
clofibrate, gemfibrozil, fenofibrate
|
fibric acid derivatives
|
|
|
what effect does fibric acid derivatives have on TG?
|
large decrease
|
