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27 Cards in this Set
- Front
- Back
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pravastatin ezetimibe |
not metabolized by cytochrome p450 |
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fluvastatin, rosuvastatin, pitavastatin |
CYP2C9 |
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atorvastatin, simvastatin, lovastatin |
CYP3A4 |
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rosuvastatin simvastatin |
statins that increase HDL |
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lovastatin simvastatin |
statin prodrugs; penetrate CNS |
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rosuvastatin |
20 hr t1/2, use less in Asians, dec LDL 63% (highest %) |
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rosuvastatin, avorvastatin |
give at any time of day (t1/2 20hr; 14hr) |
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atorvastatin |
decrease LDL 60% (2nd highest), t1/2 14 hr |
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pitavastatin |
t1/2 12 hr |
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simvastatin |
max 40mg (<80mg) -lower dose due to myopathy, lower LDL 51% (3rd best) |
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lovastatin pravastatin simvastatin |
generics |
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niacin, Gemfibrozil, Fenofibrate, ezetimibe |
NOT if gall bladder disease |
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familial combined hyperlipidemia |
overproduce apo-B100 --> inc VLDL and LDL |
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familial hypertriglyceremia |
deficient liporprotein lipase--> inc trig, VLDL |
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familial hypercholesterolemia |
defective LDL-R or defective apo-B100 (LDL not recognized) |
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niacin mechanism |
inhibits hormone sensitive lipase (--> less FFA) inhibit liver clear. of ApoA-I -->ApoAI--> inc HDL but inc cholesterol and bile acid secretion |
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fibric acid derivatce (fenofibrate, gemfibrozil) mechanism |
inhibit lipogenesis (liver FA--> trig) inhibit Apo CIII (so incr. LPL-->inc musc metab) incr. synth. Apo-AI, AII ---> incr. HDL incr. size LDL |
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gemfibrozil |
competes with glucaronidation of statins (increased myopathy) |
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bile acid binding resin mechanism (cholestyramine, colestipol, colesevelam) |
bind bile acid - insoluble complex can't be reabsorbed --> decr. chol in liver--> proteases activate SREBP to bind SRE--> incr. LDL-R |
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cholestyramine colestipol (not colesevelam) |
decr. uptake ADEK, warfarin, statins, folic acid; constipation, bloat, indigestion |
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statin mechanism |
HMG-CoA analog -- inhibit HMG-CoA reductase synthesis of mevalonate |
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all statin drug-drug interaction |
extensive first pass uptake by OATP1B1 |
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ezetimibe (zetia) |
selectively inhibit intestinal absorption of cholesterol at brush border small intest. (liver --> glucuronide) --- cholestyramine and colestipol interfere with absorption |
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mipomersen |
inhibit apo-B100 synthesis |
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limitapide |
inhibit MTP |
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mipomersen limitapide |
S/E hepatic steatosis |
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niacin + resin + statin |
lower LDL 70% |
