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10 Cards in this Set

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Type 1 hyperlipoproteinemia treatment
Limit total daily fat intake to no more than 10-25g/day
Type IIa hyperlipoproteinemia treatment
-HMG-Co-ARI
-Cholestyramine/colestipol
-Niacin
Type IIb hyperlipoproteinemia treatment
-Statins
-Fibrates
-Niacin
Types III, IV, V treatment
-Fibrates
-Niacin
Niacin MOA
Reduces VLDL synthesis -> reduces LDL synthesis
Niacin side effects
-cutaneous flushing
-hyperuricemia
-hyperglycemia
-increased LFTs
-acanthosis nigricans
Concomitant use of what should be avoided at the time of ingestion of niacin due to increased flushing and pruritus
-alcohol
-hot drinks
Bile acid resins MOA
Stimulates hepatic bile acid synthesis from cholesterol--> increases cholesterol biosynthesis-->increases number of LDL receptors on hepatocyte
Bile acid resins side effects
-bloating, flatulence, constipation
Bile acid resins may aggravate this condition
hypertriglyceridemia; due to increased hepatic cholesterol biosynthesis paralled by increased VLDL production