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23 Cards in this Set
- Front
- Back
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atherosclerosis
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disease of vasculature in large and medium sized arteries; leads to heart attack
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process of atheros. (1)
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elevated LDL
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process athero. (2)
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endothelial cells respond to compensate for injury
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process athero. (3)
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monocytes go to macrophages, then foam cells
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process athero. (4)
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smooth muscle cells migrate into lesion--forms thrombus
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process athero. (5)
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secrete growth factors and cytokines, fibrous cap that walls off the lesion from the lumen
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chylomicron
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from fatty acids of dietary tg's and cholesterol
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VLDL
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very low density lipoproteins, endogenous or hepatocyte tg's
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VLDL remnants
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IDL; re-enter the circulation, some then converted to LDL
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ApoB-100
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apoprotein of LDL, ligand that binds LDL to receptor
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HDL
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has free cholesterol from cell membranes, exchange (TP)and removes cholesterol
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abnormal lipid transport
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-high LDL
-low HDL -high tg's |
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total cholesterol
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less than 200
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LDL
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less than 100
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HDL
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under 40 is low
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tg's
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less than 150
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STATINS
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HMG-CoA reductase inhibitors, less cholesterol, removes LDL from blood
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statin SE's
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hepatotoxicity, myopathy
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Bile-acid binding resins (cholestipol and cholestyramine)
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bind to neg charged bile acids, excretes cholesterol
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Bile-acid binding resins SE's
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gi upset, binds to other drugs
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Niacin
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B-complex vitamin, increases HDL, lowers LDL, inhibits lipolysis of tg's
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Fibrates
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interacts with PPARs, more clearance of tg's
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ezetimibe
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inhibits dietary cholesterol uptake by enterocytes
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