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29 Cards in this Set

  • Front
  • Back
Causes of CHD
smokin , hypertension obesity, diabetes
wich patients should receive drugs ?
over 160 mg/dl LDL levels are candidates
statins are what inhibitors ?
HMG CoA reductase inhibitors
statins effect
lowers LDL , reduces CHD
First line treatment of elevated LDL
Statins
give 3 examples of statins
Pilavastatin, Rosuvastatin, Atorvastatin
Homozygous familial hypercholesterolemia
Lack LDL receptors
not benefit from statins
Niacin can be used with
statins
Niacin increases
HDL levels
Most potent HDL increasing agent?
Niacin
Niacin inhibits?
LIPOLYSIS ,
results decreased plasma VLDL and LDL
Niacin reduces LDL by %
10 - 20%
Adverse of Niacin ?
intense cutaneus flushing , itching skin
What decreases flsuhing of niacin?
take aspirin before
Niacin inhibits tubular ?
secretion of uric acid can lead to GOUT
What lowers serum triacylglycerol and increases HDL
Fenofibrate + Gemfibrozil
Fenofibrate + Gemfibrozil treats
Type 3 hyperlipidemia
in Type 3 hyperlipidemia what accumulates
IDL
adverse of Fenofibrate + Gemfibrozil
Gi-tract , Lithiasis, Myositis
elevate sulfonylureas
not used in renal hepatic patients
Fenofibrate and Gemfibrozil are derivates of
fibric acid
Bile acid binding resins
cholestyramine
colestipol
colesevelam
cholestyramine colestipol
colesevelam binds to
negatively charged bile acids, bile salts
lowering bile acids concentration makes hepatocytes
convert cholesterol to bile acids
Bile acid binding are used in ?
type 2a and 2b hyperlipidemia
Bile acid resins advere effect
loss absorption of fat vitamins
cholesterol absorption inhibitors
Ezetimibe
Ezetimibe leads to
decreased delivery of intestinal cholesterol to liver
Ezetimibe decreases
LDL 17% triacylglycerol 6%
Ezetimibe not used in
Hepatic insuficiency