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32 Cards in this Set
- Front
- Back
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Catecholemine Inactivation
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Reuptake (inhibit w/ TCA's)
Diffusion Monoamine Oxidase Metabolism Catechol-O-Methyltransferase (COMT) |
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Alpha 1
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Smooth Muscle
↑ Cardiac Inotropy ↓ Chronotropy Uterine Contraction Bronchoconstriction |
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Alpha 2
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Presynaptic terminal
↓ adenylate cyclases ↓ Ca+ Dilation Sedation |
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Beta 1
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Heart
↑ Adenylate Cyclase + Chronotropic + Dromotropic + Ionotropic |
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Beta 2
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Smooth Muscle/Glands
↑ Adenylate Cyclase Smooth muscle relaxation ↑ Glycogen/Lipolysis, Gluconeos Insulin release ↑ Na/K pump ↓ Hyperkalemia |
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Phenylephrine
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Alpha 1 agonist
Reflex Bradycardia ↑ Coronary Artery Flow |
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Phenylephrine Dosing
Bolus Continuous |
Bolus 50 - 100 mcg
0.25 - 1.0 mcg/kg/min Onset < 1 min Duration 15 - 20 min |
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Clonidine
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Alpha 2 Agonist
Sympatholytic ↓ SVR ↓ Chronotrope ↓ Opioid muscle rigidity ↓ Post op shivering |
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Clonidine Dosing
Oral IM Transderm |
3.0 - 5.0 mcg/kg
2.0 mcg/kg 0.1 - 0.3 mg/day Onset 30 - 60 minutes |
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Epinephrine
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Beta1 - ↑ CO, Contractility, HR
↑ Myocardial O2 consumption Alpha 1 - ↓ renal/splanchnic flow ↑ Coronary/Cerebral PP, SBP Beta 2 - Bronch dilation Halothane dysrhythmia complication |
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Epinephrine Dosing
Bolus Continuous |
0.01 - 1.0 mg IV
2.0 - 20 mcg/min 1:200 000 - 5 mcg/ml 1:100 000 - 10 mcg/ml |
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Ephedrine
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Indirect (similar to Epi)
↑ BP, HR, Contractility, CO no decrease in uterine art. flow |
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Ephedrine Dosing
Bolus |
2.5 - 10 mg (5 - 10 mg)
0.1 mg/kg Peds 10 min duration |
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Norepinephrine
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Alpha 1, Beta 1&2
↑↑ Vasoconstrictor, ↑ SVR, Afterload, Myocard O2 ↓ renal |
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Norepinephrine Dosing
Bolus Continuous |
0.04 - 0.4 mcg/kg/min
4 mg/250 mL (16 mcg/mL) 2.0 - 20 mcg/min Onset < 1 min Duration 2 - 10 min |
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Dopamine Dosing
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< 2 mcg/kg/min ↑ D receptor
2 - 10 mcg/kg/min Beta 1 > 10 mcg/kg/min Alpha 1 |
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Dobutamine
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Beta 1 agonist
↑ CO, Ionotropic, slight HR ↓ slight SVR |
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Dobutamine Dosing
Continuous |
2.0 - 20 mcg/kg/min
250 mg/250 mL (1000 mcg/mL) Onset 1 - 2 min Duration < 10 min |
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Isoproterenol
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Beta 1 - ↑ HR, CO, Contractility
Beta 2 - ↓ SVR, ↓ Diastolic BP Pure Beta Agonist |
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Fenoldopam
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DA 1
↑ Renal Flow ↓ SVR |
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Fenoldopam Dosing
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1.0 mcg/kg/min
↑ Until BP reached |
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Phentolamine (Regitine)
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Alpha 1&2 competive blocker
1 - 5 mg IV bolus |
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Labetalol (Normodyne, Trandate)
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Alpha 1, Beta 1&2 blocker
↓ SVR, Art BP, HR, CO Can Cause Bronchospasm, CHF exacer. |
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Labetalol Dosing
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0.1 - 0.25 mg/kg
Onset 2 - 5 min Duration 2 - 4 hours |
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Esmolol (Brevibloc)
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Short Beta 1 Antagonist
@ induction ↓ Tachycard, HTN Erythrocyte Esterase |
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Esmolol Dosing
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0.2 - 0.5 mg/kg
50 mcg/kg/min Onset 1 - 2 min 1/2 life 2 min |
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Metoprolol
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Beta 1 Antagonist
↓ HR, BP 2 mg followed by 1 mg |
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Nitroprusside
Dosing |
NO -> Guanylate cyclase
0.5 - 10.0 mcg/kg/min Onset 30 - 60 sec Duration 1 - 10 min |
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Nitroglycerine (Tridil, Nitrostat)
Dosing |
NO -> Guanylate cyclase
50 mcg bolus 0.5 - 10 mcg/kg/min Onset 1 - 2 min Duration 3 - 5 min |
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Hydralazine (Apresoline)
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Forms NO
5 - 20 mg bolus Onset 5 - 20 min Duration 2 - 4 hours |
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Cardene (Nicardipine)
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Ca+ blocker
↑ Dilation Coronary Vasc Dilation |
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Cardene (Nicardipine) Dosing
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25 mg/250 mL (100 mcg/mL)
200 - 250 mcg 50 mL hour |
