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21 Cards in this Set
- Front
- Back
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What is the mechanism of sodium oxybate?
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Stimulates GABAb and GHB specific receptors --> restores sleep, treats cataplexy a/w nacolepsy
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Which class of drugs is most likely to precipitate acute intermittent porphyria in a genetically predisposed individual?
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Barbiturates
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Which drugs put you to sleep but don't keep you asleep?
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Ramelteon, Triazolam, Estazolam
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Which antidepressant is most likely to produce weight gain?
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TCA (amitryptyline)
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Which antidepressant is least likely to produce weight gain?
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Buproprion
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Which antidepressant is most likely to produce N/V?
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Fluoxetine (SSRI)
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Antipsychotic drugs carry black box warning for management of what condition in elderly?
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Alzheimer's
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What is the basis of tardive dyskinesia in antipsychotics?
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High D2 potency drugs --> uprgulation of D2 receptors
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Which antidepressant is most likely to produce orthostatic hypotension?
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TCA (amitriptyline)
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Which antidepressants are most likely to produce pharmacokinetic interactions due to inhibition of cyp450?
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SSRIs (Fluoxetine)
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Which BZDs have no active metabolites?
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TOLE
Temazepam, Oxazepam, Lorazepam, Estazolam |
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Which BDZ has the shortest duration of effect?
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Triazolam
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What is the important AE of ramelteon?
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hyperprolactinemia
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Which drugs have cross-dependence with EtOH?
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Barbs, Benzos, Opioids
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What is unique about the met of phenobarbitol and paraldehyde?
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phenobarb --> 30% renal excretion
paraldehyde --> 10-30% pulmonary |
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Which SSRI has biggest problem with motor restlessness?
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fluoxetine and sertraline
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Which antidepressants have the greatest degree of antimuscarinic effects?
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TCAs (Amitriptyline)
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Which antipsychotics have high potential of tardive dyskinesia?
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high D2 potency typicals --> haloperidol
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Which antidepressant is used to manage insomnia?
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Trazodone (5HT2a and SERT inhibition)
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Which SSRI takes longest to clear from the body?
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Fluoxetine (180)
Sertraline (80) |
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Which drugs are used most frequently to manage anxiety?
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SSRI (fluoxetine) --> Rx panic attack and GAD
Alt. Buspirone --> slow onset, no dependance |
