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13 Cards in this Set
- Front
- Back
HD affects what structures most? the ____ which consists of the ____ and the _____, with the latter being affected most significantly |
certain basal ganglia structures: striatum (putamen + caudate nucleus)--caudate nucleus in particular; nucleus accumbens to a lesser extent |
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what is the triad of clinical sxs found in HD (i.e. sxs in these 3 areas)? |
motor sx, cognitive sx, behavioral sx (to be elaborated in following cards) |
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name some of the motor sxs seen in HD |
involuntary movements (usu. choreiform); unsteady gait (appear intoxicated); abnormalities in eye movements; difficulty with speech and swallowing |
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name some bx changes in HD |
personality change, depression, mood swings |
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name some npsych findings in HD when progressed (as with other subcortical dementias): deficits in the domains of ___ and ___, difficulty with the ____ aspect of memory, and ____aphasia |
executive fxs, attention; |
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on what criterion does the dx of HD traditionally rest? |
emergence of chorea (choreiform movement d/o) |
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HD is a (static/progressive) illness that is (lethal/nonlethal) with a usual onset in the __ to __ decades |
progressive (of course, as a neurodegenerative illness), lethal, 3rd to 5th |
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what tx helps to delay onset/slow decline in HD? what tx may help with chorea sxs? |
there is none presently; antidopaminergic agents |
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mood disorders occur in approx(1/4, 1/2, 3/4) of pts with HD |
1/2 |
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Huntington Study Group created the HD battery UHDRS, assessing motor, cog, bx and functional sxs. Includes these 3 tests, which are among those that are sensitive to basal ganglia dysfx: |
Stroop, Digit Symbol, Verbal Fluency |
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initial sxs in HD usually include subtle ___ and motor ______, and disturbances in ____ |
chorea, clumsiness, behavior |
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common pyschiatric manifestations of HD include _____ disorders, _____ disorder, and/or impulsive or destructive ____-like behavior |
affective, obs.compulsive, manic |
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atrophy of the caudate and putamen in HD can cause the __________ to appear enlarged in MRI or CT scans |
lateral ventricles |